What is the cutoff time for Rotarod?
Features
| Parameter | Mode | |
|---|---|---|
| Normal | Acceleration II | |
| Speed | 0.1-80 rpm (selectable fixed) | 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80 rpm |
| Acceleration Time | N.A. | 60, 120, 180, 240, 300 sec |
| Cut Off Time | 1.0 sec to 999.9 sec | 301.0 sec to 999.9 sec |
What does Rotarod assay measure?
The rotarod test is used to assess motor coordination and balance in rodents.
What parameter is recorded in rotarod test?
The rotarod performance test is a performance test based on a rotating rod with forced motor activity being applied, usually by a rodent. The test measures parameters such as riding time (seconds) or endurance.
How does a rota rod work?
Once all animals are placed, the ROTOR-ROD “Start” button is pressed and the rod begins rotating. The rotation is controlled by a speed control ramp previously defined by the user. The speed control ramp is constructed of segments that are accelerating, constant or decelerating in any mix.
Which drug is used in RotaRod?
In the rotarod test, antidepressant drugs such as imipramine (30 mg/kg, p.o.), desipramine (10 mg/kg, p.o.), clorgyline (10 mg/kg, p.o.), mianserin (30 mg/kg, p.o.), trazodone (10 mg/kg, p.o.) and clomipramine (30 mg/kg, p.o.) and an ACE inhibitor, enalapril (30 mg/kg, p.o.), significantly prolonged the time rats were …
What is the purpose of a RotaRod?
The rotarod test is widely used to evaluate the motor coordination of rodents, and is especially sensitive in detecting cerebellar dysfunction.
Which drug is used in Rotarod?
What is the principle of Rotarod apparatus?
Rotarod test is widely used to evaluate drug effects on motor coordination, balance and motor learning in rodents. The principle of this test is that rats or mice are first trained to walk on a rod rotating at a certain speed.
What is rota rod apparatus?
The RotaRod test is one of the oldest tests used for assessing motor coordination and balance in rodents. It provides a quick and simple estimation of neuromuscular coordination. The apparatus consists of a motorized, circular rod turning at a constant or increasing speed.
What is the purpose of a rotarod test?
What is Rotarod used for?
Who invented RotaRod?
Ugo Basile
Ugo Basile designed the first industrial RotaRod in the 1960s. The name we coined soon became so popular, now everybody knows this instrument as RotaRod! The Rota-Rod is the reference test to screen drugs potentially active, or having side effects, on motor coordination.