Is chloroquine acidic or basic?
Because chloroquine is a weak base, it increases vesicle pH by that mechanism in chloroquine-susceptible and resistant parasites and mammalian cells (based on its two pKs and on the delta pH between the acid vesicle and the extracellular environment).
Does chloroquine increase pH?
Chloroquine analog is a diprotic weak base. The unprotonated form of chloroquine diffuses spontaneously and rapidly across the membranes of cells and organelles to acidic cytoplasmic vesicles such as endosomes, lysosomes, or Golgi vesicles and thereby increases their pH (Al‐Bari 2015).
What are the chemical properties of chloroquine?
3.1Computed Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 319.9 |
| XLogP3 | 4.6 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
Does chloroquine dissolve in water?
Chloroquine phosphate is freely soluble in water—practically insoluble in alcohol, in chloroform and in ether.
What is chloroquine base?
Chloroquine (also known as chloroquine phosphate) is an antimalarial medicine. It is available in the United States by prescription only. It is sold under the brand name Aralen, and it is also sold as a generic medicine. It is available in tablets of two sizes: 150mg base (250mg salt) and 300mg base (500mg salt).
Which type of drug is chloroquine?
Chloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito.
How does hydroxychloroquine increase pH?
Chloroquine and hydroxychloroquine increase pH within intracellular vacuoles and alter processes such as protein degradation by acidic hydrolases in the lysosome, assembly of macromolecules in the endosomes, and posttranslation modification of proteins in the Golgi apparatus.
What is the use of chloroquine?
Chloroquine is used to prevent and treat malaria. It is also used to treat liver infection caused by protozoa (extraintestinal amebiasis). Chloroquine may also be used to treat coronavirus (COVID-19) in certain hospitalized patients.
What is the chemical name of chloroquine?
Chloroquine
| Clinical data | |
|---|---|
| IUPAC name (RS)-N’-(7-chloroquinolin-4-yl)-N,N-diethyl-pentane-1,4-diamine | |
| CAS Number | 54-05-7 |
| PubChem CID | 2719 |
| IUPHAR/BPS | 5535 |
How do you dissolve chloroquine?
This can be explained as: chloroquine diphosphate is a salt and has a strong polarity. Therefore, a highly polar solvent such as water can easily dissolve it. The results show that the solubilities of chloroquine diphosphate and 4,7-dichloroquinoline in different solvents increase smoothly with increasing temperature.
How do you make chloroquine solution?
Chloroquine Preparation and Recipe
- Prepare 800 mL of distilled water in a suitable container.
- Add 52 g of Chloroquine diphosphate to the solution.
- Add distilled water until the volume is 1 L.
- Sterilize the solution by passing it through a 0.22-µm filter; store the filtrate in foil-wrapped tubes at -20°C.
What is the chemical composition of chloroquine?
C18H26ClN3Chloroquine / Formula
What is another name for chloroquine?
Chloroquine (also known as chloroquine phosphate) is an antimalarial medicine. It is available in the United States by prescription only. It is sold under the brand name Aralen, and it is also sold as a generic medicine.
Can chloroquine cause kidney damage?
It is concluded that chloroquine administration impairs kidney function, resulting in inappropriate Na+ and Cl- retention. This effect is likely to be mediated via chloroquine-induced increases in plasma aldosterone concentration and lowering of GFR.
What is the half life of hydroxychloroquine?
Pharmacokinetics: Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours (22.4 days).
Does hydroxychloroquine cause hair loss?
Hair loss is not a documented side effect of Plaquenil. If it does occur, it is so extremely rare that it is not documented in the literature. In fact, hydroxychloroquine is actually used to prevent hair loss from other medications.
How long can I take chloroquine?
How long is it safe to use chloroquine? CDC has no limits on the use of chloroquine for the prevention of malaria. When chloroquine is used at higher doses for many years, a rare eye condition called retinopathy has occurred. People who take chloroquine for more than five years should get regular eye exams.
What is base in chloroquine?
What is the half life of chloroquine?
Chloroquine is extensively distributed with an enormous total apparent volume of distribution (Vd) more than 100 L/kg, and a terminal elimination half-life of 1 to 2 months.
How do you store chloroquine?
Store at room temperature (15-25 °C). Protect from light. – Upon resuspension, chloroquine should be stored at 4 °C. The reconstituted product is stable for 1 month at 4 °C.
What is the brand name for chloroquine?
Who should not take chloroquine?
Eye or vision problems (eg, retinal or visual field changes) caused by 4-aminoquinoline compounds—Should not be used in patients with these conditions.
How long can you take chloroquine?
What are the negative effects of chloroquine?
nausea, vomiting, diarrhea, stomach cramps; headache; unusual changes in mood or behavior; hair loss; or.
How quickly does hydroxychloroquine work?
Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it’s a long-term treatment it’s important to keep taking hydroxychloroquine unless you have severe side effects: even if it doesn’t seem to be working at first.