What is a coumarin derivative?
Coumarin derivatives (4-hydroxycoumarin compounds) are oral anticoagulants (OA) that prevent vitamin K from acting as a cofactor in the hepatic synthesis of the vitamin K-dependent coagulation factors II, VII, IX, and X (as well as the anticoagulants, proteins C and S).
Is coumarin a natural product?
Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective …
Is coumarin natural or synthetic?
Natural
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds.
What is coumarin used for?
Coumarins are commonly used in the treatment of prostate cancer, renal cell carcinoma and leukemia, and they also have the ability to counteract the side effects caused by radiotherapy. Both natural and synthetic coumarin derivatives draw attention due to their photochemotherapy and therapeutic applications in cancer.
Is coumarin toxic to humans?
The mechanism of coumarin-induced tumour formation in rodents is associated with metabolism-mediated, toxicity and it is concluded that exposure to coumarin from food and/or cosmetic products poses no health risk to humans.
What effect does coumarin have on the body?
Despite its sweet flavor and pleasant aroma, coumarin is a chemical that can have serious effects on health when consumed in high amounts. In fact, high doses have been linked to liver damage, impaired cognitive development and even cancer formation in both animal and human studies.
What are side effects of coumarin?
Side Effects of COUMARIN
- Dizziness.
- Headache.
- Blood in urine and stools.
- Stomach pain.
- Hair loss.
Why coumarin is not healthy?
Animal studies have shown that eating too much coumarin, which is abundant in Cassia cinnamon, may increase the risk of certain cancers ( 3 ). For example, studies in rodents have found that eating too much coumarin can cause cancerous tumors to develop in the lungs, liver, and kidneys (8, 9, 10 ).
What foods are high in coumarin?
Coumarin is a naturally occurring sweet-smelling compound found in many plants, including cinnamon, tonka beans, and sweet clover. High amounts of coumarin can be found in cassia cinnamon (also known as true cinnamon), whereas the Ceylon variety typically contains only traces.