What are the zones of endochondral ossification?
In endochondral ossification: The bone is formed onto a temporary cartilage model. The cartilage model grows (zone of proliferation), then chondrocytes mature (zone of maturation) and hypertropy (zone of hypertrophy), and growing cartilage model starts to calcify.
What are the 4 zones of bone growth?
The long bone in a child is divided into four regions: the diaphysis (shaft or primary ossification centre), metaphysis (where the bone flares), physis (or growth plate) and the epiphysis (secondary ossification centre).
What are the 5 steps of endochondral ossification?
Endochondral Ossification
- Reserve Zone. Storage site for lipids, glycogen, proteoglycan.
- Proliferative Zone. Proliferating chondrocytes leading to longitudinal growth.
- Hypertrophic Zone. Site of chondrocyte maturation.
- Primary Spongiosa. Site for mineralization to form woven bone.
- Secondary Spongiosa.
Where is the zone of ossification?
Zone of ossification: Osteoblasts deposit bone matrix on the exposed plates of calcified cartilage. Zone of resorption: Osteoclasts absorb the oldest ends of the bone spicules. Note the high vascular density in this area: one capillary loop for each chondrocytic column.
What are the 7 steps of endochondral ossification?
Terms in this set (7)
- enlargement of cartilage in chondrocytes.
- blood vessels grow into shaft.
- fibroblasts migrate to bone center and differentiate into osteoblasts.
- bone enlarges.
- centers of epiphysis calcify.
- epiphysis fills with spongy bone.
- during puberty: cartilage production slows while osteoblast activity increases.
What are the 5 zones of the epiphyseal plate?
Match
- Zone of… -resting Cartilage.
- Zone of resting cartilage. -Farthest from the Medullary cavity and nearest epiphysis.
- Zone of proliferating cartilage. -larger chondrocytes undergoing a rapid mitotic cell division.
- Zone of hypertrophic cartilage.
- Zone of calcified cartilage.
- zone of ossification.
What are the 6 steps of endochondral ossification?
Terms in this set (6)
- Cartilage enlarges; Chondrocytes die.
- blood vessels grow into perichondrium; cells convert to osteoblasts; shaft becomes covered with superficial bone.
- more blood supply and osteoblasts; produces spongy bone; formation spreads on shaft.
- Osteoclasts create medullary cavity; appositional growth.
What are the 6 major steps in endochondral ossification?
What are the 5 stages of bone growth?
30.2A: Stages of Bone Development
- EXAMPLES.
- Initial Bone Formation.
- Intramembranous Ossification.
- Endochondral Ossification.
- Remodeling.
How do you remember zones of bone growth?
A mnemonic for remembering the names of the epiphyseal growth plate zones is: Resting zone, Proliferative zone, Hypertrophic cartilage zone, Calcified cartilage zone, Ossification zone [2,3].
How do you remember the zones of the epiphyseal plate?
A mnemonic for remembering the names of the epiphyseal plate growth zones is ” Real People Have Career Options,” standing for: Resting zone, Proliferative zone, Hypertrophic cartilage zone, Calcified cartilage zone, Ossification zone.
What is the correct steps in the process of endochondral ossification?
1) Enlarged chondrocytes die. 2) Osteoblasts replace calcified cartilage with spongy bone. 3) Chondrocytes enlarge and the surrounding matrix begins to calcify. 4) Blood vessels grow around the edges of the cartilage.
Which zone of endochondral ossification contains the largest cells?
The cells swell in the hypertrophic zone, where the columns become more organized. The chondrocytes in this zone are surrounded by increasing amounts of extracellular matrix, which becomes mineralized in the zone of calcification.
What zone of the endochondral ossification is closest to the epiphyseal plate?
The reserve zone
The reserve zone is the region closest to the epiphyseal end of the plate and contains small chondrocytes within the matrix.