What is Cinacalcet Hydrochloride used for?
Cinacalcet is used to treat hyperparathyroidism in patients with chronic kidney disease who are on dialysis. Hyperparathyroidism is a condition that is caused when the parathyroid glands located in the neck make too much parathyroid hormone (PTH).
What is the brand name for cinacalcet?
Cinacalcet is a calcium sensing receptor agonist used to treat secondary hyperparathyroidism in chronic kidney disease and hypercalcemia in parathyroid carcinoma. Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe.
What are the side effects of taking cinacalcet?
Side Effects
- Nausea, vomiting, or unusual tiredness may occur.
- Cinacalcet can cause low calcium blood levels.
- Tell your doctor right away if you have any serious side effects, including: black/bloody stools, stomach/abdominal pain, vomit that contains blood or looks like coffee grounds.
How long does it take cinacalcet to work?
Clinical studies have shown that PTH response to cinacalcet is rapid, with nadir PTH concentration occurring approximately 3 hours after dosing; PTH concentrations remain suppressed at 24 hours as compared with baseline [12].
How long can you take cinacalcet for?
Cinacalcet was safe and generally well tolerated at doses up to 180 mg/day. Conclusions: In this long-term study, cinacalcet effectively sustained reductions in PTH for up to 3 years without increasing concentrations of serum calcium, phosphorus or calcium-phosphorus product.
What are the main side effects of cinacalcet?
How quickly does cinacalcet work?
How long does it take for cinacalcet to reduce calcium?
In this study, cinacalcet consistently decreased serum calcium and increased serum phosphorus in patients with PHPT. Patients experienced a rapid decrease in hypercalcemia after 3 months of treatment, with normalization in 55% of cases and stabilization of these changes at 12-month follow up.
How long does it take for cinacalcet to lower calcium?
In this study, treatment with cinacalcet resulted in lower serum calcium concentrations as well as consistent reductions in iPTH 2–4 h after the morning dose, as has been shown in patients with mild PHPT (8).
What is the best time of day to take cinacalcet?
It is best to take this medicine with food or shortly after a meal. Swallow the tablet whole. Do not crush, break, or chew it.