How common is hearing loss with cisplatin?
Dose-related ototoxicity is illustrated by the report that 20% of patients treated with cisplatin for testicular cancer experience permanent ototoxicity, but > 50% of patients who received cisplatin in doses > 400 mg/m2 cumulative dose had permanent hearing loss (Bokemeyer et al.
Does cisplatin cause ototoxicity?
In clinical practice, ototoxicity is the major dose-limiting side effect of cisplatin, requiring discontinuation and replacement by another second-line chemotherapeutic agent, usually carboplatin, or accepting the hearing loss, which is sometimes severe.
How common is ototoxicity?
The cisplatin ototoxicity occurs between 23% and 50% in adults and up to 60% in children [4,6]. However, some studies have reported elevated hearing thresholds in up to 100% of cisplatin-treated cancer patients [7,8], while it is estimated to be 63% with aminoglycosides and 6-7% with furosemide [9].
Is cisplatin induced hearing loss permanent?
It is used to treat a wide variety of solid tumors in both pediatric and adult patients with cancer. The incidence that you see of cisplatin-induced hearing loss varies widely, but around 50% of all patients treated with cisplatin will experience a significant, permanent hearing loss.
Does tinnitus from cisplatin go away?
Radiotherapy or the chemotherapy drug cisplatin may cause ringing or other sounds in the ears. This is called tinnitus. It may improve gradually after treatment ends but sometimes it can be permanent. Your cancer specialist will tell you if there is a chance that treatment may affect your hearing.
Why does cisplatin cause tinnitus?
The stria vascularis helps maintain the positive electrical charge in inner ear fluid that certain cells need to detect sound. The research team determined that the accumulation of Cisplatin in the stria vascularis portion of the inner ear contributed to Cisplatin-related hearing loss.
What are the most common ototoxic drugs?
The most common reported ototoxic drugs in clinical use are aminoglycoside antibiotics, macrolide antibiotics, salicylates, chemotherapeutic agents such as cisplatin, loop diuretics, antimalarials, non-steroidal anti-inflammatory drugs (NSAIDs), quinine, and acetaminophen (Rybak & Ramkumar, 2007; Tabuchi et al., 2011; …
How quickly does ototoxicity start?
Symptoms of ototoxicity may develop rapidly or over the course of months, depending on the drug involved and other factors.
Is cisplatin hearing loss reversible?
“[Cisplatin] is one of the most widely used anticancer drugs on the planet, and it’s saving a lot of lives,” Dr. Cunningham said. But the hearing loss is permanent. “So these patients are surviving and they have this hearing loss for the rest of their lives.
Can hearing loss from chemo be reversed?
Hearing loss or tinnitus caused by the drugs typically doesn’t go away. The damage tends to be cumulative and slow to progress, though, so most doctors first test patients’ hearing to determine a baseline, then monitor their reaction to a certain drug, changing the dose or the drug itself, if needed.
How long does tinnitus last after chemo?
Is ototoxic tinnitus reversible?
Ototoxicity may be reversible or may be permanent, depending on the type of medication used, dosage and duration of treatment.
What are five common medications that are potentially ototoxic and may cause hearing loss?
Ototoxic medicines that may cause hearing loss include aminoglycosides, macrolide antibiotics, antimalarials, platinum-based antineoplastic agents, anti-inflammatory medicines and loop diuretics (Table 1)2.
What are the most ototoxic drugs?
The most common reported ototoxic drugs in clinical use are aminoglycoside antibiotics, macrolide antibiotics, loop diuretics, antimalarials, chemotherapeutic agents such as cisplatin, non-steroidal anti-inflammatory drugs (NSAIDs), quinine, and acetaminophen.
How do you reverse ototoxicity?
So far there’s no sure way to reverse it. The good news is that sometimes the ear just needs time to heal. And some kids may have no further hearing or balance problems if they can stop taking the medicine that’s causing their symptoms. Sometimes, doctors might change the dosage or the medicine.
How long does cisplatin side effects last?
Nausea and vomiting usually begin within 1 to 4 hours after treatment and last up to 24 hours. Various degrees of vomiting, nausea and/or anorexia may persist for up to 1 week after treatment.
How long does it take to clear cisplatin?
The researchers also conducted postmortem analysis of inner ear tissue of human patients who had received cisplatin, and found that platinum was retained in cochleae at least 18 months after the last treatment.
How long does it take for cisplatin to leave your system?
The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months.
Is tinnitus from chemo permanent?
If you experience any changes in your hearing or ringing in your ears at any time during your treatment, it is essential to notify your physician immediately, because it is important to get a hearing test. One of the challenges with hearing loss induced by chemotherapy is that it is often permanent.
How do I get rid of ototoxicity?
How do you Treat Ototoxicity? There is no treatment to reverse the effects of ototoxicity. Sometimes, the ear may heal spontaneously when the treatment with the ototoxic drugs is completed or the drug or chemical exposure is stopped early.
Is ototoxic hearing loss reversible?
Research continues on ways to prevent ototoxicity or fix the damage it can cause. So far there’s no sure way to reverse it. The good news is that sometimes the ear just needs time to heal. And some kids may have no further hearing or balance problems if they can stop taking the medicine that’s causing their symptoms.
Does ototoxicity go away?
Ototoxicity can be temporary or permanent. The effect of certain drugs is often temporary, while other drugs typically produce permanent changes to the ear.
Why is cisplatin so toxic?
Cisplatin causes damage to nuclear and mitochondrial DNA and production of reactive oxygen species (ROS) which lead to activation of both mitochondrial and non-mitochondrial pathways of apoptosis and necrosis. Mitochondrial energetics are also disrupted by cisplatin and may contribute to nephrotoxicity.
How many cycles of cisplatin can you have?
You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months.