What are the physiological significance of gangliosides?
Gangliosides are enriched in cell membrane microdomains (“lipid rafts”) and play important roles in the modulation of membrane proteins and ion channels, in cell signaling and in the communication among cells.
What is GM1b?
GM1b is a new member of antigen for serum antibody in Guillain-Barré syndrome. Neurology.
What type of antibody is asgm1?
Asialo GM1 Polyclonal Antibody, Functional Grade, eBioscience
| Product Specifications | |
|---|---|
| Class | Polyclonal |
| Type | Antibody |
| Conjugate | Functional Grade |
| Form | Lyophilized |
What is GM1 receptor?
GM1 consists of a sialic acid-containing oligosaccharide covalently attached to a ceramide lipid. The A1 subunit of this toxin will gain entry to intestinal epithelial cells with the assistance of the B subunit via the GM1 ganglioside receptor.
What is Bickerstaff syndrome?
Bickerstaff brainstem encephalitis (BBE) is an immunologic disease characterized by the acute onset of external ophthalmoplegia, ataxia, and consciousness disturbance, mostly subsequent to infection. BBE is considered to be a variant of Fisher syndrome (FS), which also exhibits external ophthalmoplegia and ataxia.
Where is GM1 found?
Within the cells, GM1 is associated both to plasma membranes and to intracellular structure, undergoing metabolic processes by the formation of a number of products of both catabolic and biosynthetic origin [62].
What causes GM1 Gangliosidosis?
GM1 gangliosidosis type 1 is also known as the classic infantile form. GM1 gangliosidosis is caused by genetic changes in the GLB1 gene and is inherited in an autosomal recessive manner.
What is GM2 stand for?
GM2
| Acronym | Definition |
|---|---|
| GM2 | General MIDI 2 |
| GM2 | Disialotetrahexosylganglioside |
| GM2 | Gunner’s Mate Second Class (USN Rating) |
What is NK cell depletion?
Natural killer (NK) cells contribute to establishment of persistent lymphocytic choriomeningitis virus (LCMV) infection in mice through suppression of virus-specific T cell responses during the first few days of infection, but NK cell depletion during those early time points can enable severe T cell-mediated immune …
Can Covid cause Miller Fisher?
Miller-Fisher syndrome, a rare variant of Guillain-Barré syndrome (GBS), has been reported after COVID-19 infection.
How rare is Bickerstaff encephalitis?
Bickerstaff’s brainstem encephalitis (BBE) is characterised by progressive bilateral ophthalmoparesis and ataxia with impaired consciousness and/or pyramidal signs. A Japanese survey estimated the annual incidence of BBE as 0.078/100 000, with an annual onset of 100 cases.
What type of receptor is GM1?
What is anti asialo GM1?
ASGM1 is localized in lipid raft structures in NK and CD8 (+) T cells. Anti asialo GM1 antibody reduces natural killer (NK) activity in cells of various strains of mice and rats. To investigate the function of NK cells, or transplant tumor tissue derived from the other species to mice, Anti asialo GM1 antibody is injected to remove NK cells 1)2).
Does anti–asialo GM1 prevent CD8 + T cell expansion?
Anti–asialo GM1 prevents CD8 + T cell expansion. CFSE-labeled B6 T cells were adoptively transferred into irradiated (18 Gy) Balb/c recipients treated with rabbit IgG or anti–asialo GM1.
Is asialo GM1 expressed in B6 mice?
Asialo GM1 is expressed on NK cells, NK T cells, and subsets of γδ T cells and CD8 + T cells in B6 mice. Although anti–asialo GM1 antibodies are widely used to deplete NK cells, it is known that asialo GM1 expression is not confined to NK cells.