What does Hyperploidy mean?
Definition. A chromosomal abnormality in which the chromosomal number is greater than the normal diploid number. [
Is Hyperdiploid trisomy?
More than half of MM cases, instead, have a hyperdiploid karyotype, characterized by trisomies involving odd chromosomes. In several studies, trisomic MM is associated with a favorable outcome3,5.
What is Hyperdiploid multiple myeloma?
Hyperdiploid multiple myeloma (H-MM) is the most common form of myeloma. In this gene expression profiling study, we show that H-MM is defined by a protein biosynthesis signature that is primarily driven by a gene dosage mechanism as a result of trisomic chromosomes.
What is high Hyperdiploidy?
High hyperdiploidy (51–65 chromosomes, HeH) is an established genetic subtype of B-cell precursor acute lymphoblastic leukaemia (BCP-ALL), which is associated with a favourable prognosis, especially in children.
What does Heteroploidy mean?
Heteroploidy is the existence of cells, tissues, or whole organisms with numbers of chromosomes per nucleus that are different from the normal 1N or 2N complement for the particular organism.
What is Hyperdiploid karyotype?
Hyperdiploidy with greater than or equal to 50 chromosomes is a frequent and distinct karyotypic pattern in the malignant cells of children with acute lymphoblastic leukemia.
What is the fish test for multiple myeloma?
The most commonly run genetics test is called the FISH test. A fluorescence in situ hybridization test (FISH) maps out the genetic material of a cell. It uses special fluorescent dyes that only attach to specific parts of chromosomes.
What is Hypoploidy and Hyperploidy?
Aneuploidy can be either due to loss of one or more chromosomes (hypoploidy) or due to the addition of one or more chromosomes to complete the chromosome complement (hyperploidy). Hypoploidy is mainly due to the loss of a single chromosome, monosomes (2n-1) or due to loss of a pair of chromosomes, nucleosomes (2n-2).
What is the meaning of Allopolyploid?
Definition of allopolyploid : a polyploid individual or strain having a chromosome set composed of two or more chromosome sets derived more or less complete from different species.
What is Autotetraploid?
Definition of autotetraploid : an individual or strain whose chromosome complement consists of four copies of a single genome due to doubling of an ancestral chromosome complement.
What is Calla positive?
Common acute lymphoblastic leukemia-associated antigen (CALLA)-positive B cell lymphoma.
Can myeloma be misdiagnosed?
Since multiple myeloma symptoms can be mistaken for other ailments, and in some cases, symptoms may not be present at all, it’s important to know the warning signs and what can put you at risk of developing the disease.
What is high risk multiple myeloma?
In addition to cytogenetic factors, high-risk multiple myeloma may be defined by clinical features, such as plasma cell leukemia, extramedullary disease, circulating plasma cells, renal failure, and, more recently, frailty.
What does Amphidiploid mean?
Definition of amphidiploid : an interspecific hybrid having a complete diploid chromosome set from each parent form. — called also allotetraploid.
What is meant by Allohexaploid?
Adjective. allohexaploid (not comparable) (genetics) Having six complete sets of chromosomes derived from different species.
What is Allohexaploid?
What is Calla in ALL?
The common acute lymphoblastic leukemia antigen (CALLA) is a 749-amino acid type II integral membrane protein expressed by most acute lymphoblastic leukemias, certain other lymphoid malignancies with an immature phenotype, and normal lymphoid progenitors.
What is Calla marker?
Common acute lymphoblastic leukemia antigen (CALLA) is an early marker of B-cell differentiation. • Useful in differential diagnosis of B-cell lymphoproliferative disorders (see Table 1.2)
What does hyperdiploidy mean?
What is Hyperdiploidy? Hyperdiploidy (chromosomal number 51‐65) is a common cytogenetic abnormality in pediatric patients with B‐lymphoblastic leukemia (B‐ALL) and belongs to the favorable cytogenetic subgroup. Hyperdiploidy in adult B‐ALL is much less common and its clinical significance has not been well studied.
What is the difference between a haploid, diploid, and zygote?
chromosomes are made of DNA What is the difference between a haploid, diploid, and zygote? Haploid: represented by letter N, half set of chromosomes, gamete Diploid: represented by 2N, pairs of chromosomes, body or somatic Zygote: created when sperm enters egg, Diploid, Diploid
What does haploid mean?
The word haploid (meaning ‘half’) describes a cell that contains a single set of chromosomes. Diploid cells contain two sets of chromosomes, which are arranged in homologous pairs. The body (AKA somatic) cells of most organisms are diploid, and only their gametes are haploid.
What is diploid and haploid?
Diploid is a cell or organism that has paired or two sets of chromosomes, one from each parent. Haploid or monoploid is a cell or organism that has just a single copy of each chromosome. Cell division. These cells are formed after mitotic cell division. These cells are formed after meiotic cell division.