What drugs Cannot be used with warfarin?
Common drugs that can interact with warfarin include:
- Aspirin or aspirin-containing products.
- Acetaminophen (Tylenol, others) or acetaminophen-containing products.
- Antacids or laxatives.
- Many antibiotics.
- Antifungal medications, such as fluconazole (Diflucan)
- Cold or allergy medicines.
What happens when rifampin is given with warfarin?
Rifampin’s concomitant use with warfarin results in a clinically significant drug–drug interaction. This interaction leads to accelerated warfarin’s clearance and ultimately a reduction in its anticoagulant effect (Strayhorn et al.
Which medication should be avoided when a resident is on warfarin?
Common OTC medicines that affect warfarin:
Aspirin. Ointments and skin creams with aspirin, such as Aspercreme. Pepto-Bismol® and Alka-Seltzer. Nonsteroidal anti-inflammatory drugs, such as ibuprofen (Motrin® or Advil®) or naproxen (Aleve®)
What drugs increase INR with warfarin?
Warfarin drug interactions
| Drug/Drug Class | Effect on INR | Proposed Mechanism |
|---|---|---|
| cimetidine | increased | Inhibition of Warfarin Metabolism |
| ciprofloxacin | increased | Inhibition of Warfarin Metabolism |
| clarithromycin | increased | Inhibition of Warfarin Metabolism |
| clofibrate | increased | Unexplained Mechanisms |
What foods affect warfarin?
Avoid or drink only small amounts of these when taking warfarin: Cranberry juice. Grapefruit juice. Alcohol.
…
Vitamin K-rich foods include:
- Kale.
- Spinach.
- Brussels sprouts.
- Collard greens.
- Mustard green.
- Turnip greens.
- Swiss chard.
- Broccoli.
How long can you stay on warfarin?
If you take warfarin to reduce your risk of having a blood clot in future or because you keep getting blood clots, it’s likely your treatment will be for longer than 6 months, maybe even for the rest of your life.
What does rifampin do to INR?
Rifampicin suppresses the anticoagulant activity of warfarin, which can lead to a need for increased doses of warfarin to achieve and maintain a therapeutic INR. More frequent INR monitoring is needed even after discontinuing rifampicin.
Does rifampin inhibit warfarin?
Rifampicin is a liver enzyme inducer[7] that has a significant impact on the rational use of warfarin[8,9]. Rifampicin induces aromatic hydroxylated cytochrome P-450 isoenzyme CYP2C9 to accelerate the clearance of warfarin used in combination, thereby affecting the anticoagulant effect of warfarin[8].
What is the most common side effect of warfarin?
Warfarin (also known under the brand name Coumadin), a blood thinner that has been around for decades, can trigger a range of side effects. Some of the side effects include nausea, vomiting, diarrhea and abdominal pain. The most common side effect — bleeding — can be life-threatening.
Can I drink coffee while on warfarin?
It was concluded that caffeine has the capacity to inhibit the metabolism of warfarin and enhance its plasma concentration and hence anticoagulant effects. Thus, patients should be advised to limit the frequent use of caffeine-rich products i.e. tea and coffee during warfarin therapy.
What is a critical INR level?
Normal and Critical Findings
INR levels above 4.9 are considered critical values and increase the risk of bleeding.
What is the normal range of INR?
In healthy people an INR of 1.1 or below is considered normal. An INR range of 2.0 to 3.0 is generally an effective therapeutic range for people taking warfarin for disorders such as atrial fibrillation or a blood clot in the leg or lung.
Can you eat eggs while on warfarin?
Foods You Can Eat on a Warfarin Diet
On the positive side, patients are able to consume many foods considered safe if they are taking any anticoagulants. These are the foods that are considered safe to consume: Meat, fish, and eggs.
Can you eat bananas when taking warfarin?
If you are a patient on warfarin, wondering whether it’s on your list of foods you can eat without worry shouldn’t make you crazy. The only time to be a little cautious when eating bananas is when you prepare green bananas.
Can you live a normal life on warfarin?
I take warfarin, although there are several different types of blood thinners available today. Life with blood thinners can be overwhelming at first, but eventually, you can still live a very normal life with these medications.
What is the safest blood thinner to use?
Safer Blood-Thinning Drugs to Prevent Stroke
The newer medications are Pradaxa (dabigatran), Xarelto (rivaroxaban), Eliquis (apixaban), and most recently Savaysa (edoxaban) — which work by preventing pooled blood in the heart from clotting. Unlike warfarin, the newer drugs are safer and easier for patients to use.
Does rifampin increase warfarin levels?
Rifampin has been reported to increase the warfarin requirements in human subjects ingesting these agents simultaneously. The concomitant administration of rifampin and warfarin resulted in the need for an unusually high maintenance dose of warfarin (20 mg per day) in order to produce a therapeutic effect.
What drugs interact with rifampin?
Studies and case reports have demonstrated that rifampin accelerates the metabolism of several drugs, including oral anticoagulants, oral contraceptives, glucocorticoids, digitoxin, quinidine, methadone, hypoglycemics, and barbiturates.
Does warfarin affect sleep?
Warfarin oral tablet doesn’t cause drowsiness. However, it can cause other side effects.
Does warfarin make you tired?
Global rating for change in fatigue intensity showed no increase of fatigue with warfarin use. Conclusions: The short-term use of warfarin was not associated with symptoms of fatigue.
Does drinking water affect INR levels?
What you eat and drink can also affect your INR. The more consistent you are in what you eat and drink, the easier it can be to regulate your dose of Warfarin and keep your INRs in range.
Can a high INR cause a stroke?
Elevated International Normalized Ratio Is Associated With Ruptured Aneurysms | Stroke.
What is the danger level for INR?
A value higher than 3.5 increases the risk of bleeding problems.
Can you eat potatoes while taking warfarin?
This doesn’t mean that you have to avoid these vegetables, however; you simply need to consume approximately the same amount each day. You can also choose from low vitamin K vegetables such as carrots, potatoes, celery, peas, peeled cucumbers, peppers, eggplant, tomatoes and zucchini.