What is a dendrimer used for?
Due to their size, dendrimers are used in nanomedicine research. They are found to be useful as delivery or carrier systems for drugs and genes, but studies have shown that some dendrimers have medicinal uses of their own, mostly due to their antifungal, antibacterial and cytotoxic properties [5,6].
Which is the example of dendrimer?
Examples of several types of dendrimers include those which have immense applications in drug delivery including poly(amidoamine) (PAMAM) dendrimers, poly(propylene imine) (PPI) dendrimers, polyether-copolyester (PEPE) dendrimers, PEGylated dendrimers, peptide dendrimers, etc.
What is dendrimer nanotechnology?
Abstract. Dendrimers represent a class of novel polymers having unique molecular architectures characterized by their well-defined structure, with a high degree of molecular uniformity, low polydispersity and properties that make them attractive materials for the development of nanomedicines.
What is dendrimers Slideshare?
Dendrimer Polymers techniques is a controlled release system which helps to s… rita martin. Dendrimers for drug delivery p1. tabirsir. Dendrimers : A recent drug delivery system.
What is a dendrimer made of?
Dendrimers are nearly monodisperse macromolecules that contain symmetric branching units built around a small molecule or a linear polymer core [5-7]. ‘Dendrimer’ is only an architectural motif and not a compound.
How is dendrimer different from a polymer?
Dendrimers are hyperbranched macromolecules having a perfectly defined and highly functionalized repetitive structure. In contrast to all the other types of polymers, they are not synthesized by polymerization reactions but step by step (‘layer after layer’), which allows a perfect control of their structure.
What are dendrimers made of?
What are the different ways of drug loading in dendrimers?
The dendrimer architecture has three main sites for drug entrapment by using various mechanisms: (i) void spaces (by molecular entrapment); (ii) branching points (by hydrogen bonding); and (iii) outside surface groups by (charge–charge interactions) (Figure 1).
Is dendrimer a nanoparticle?
Dendrimers are nano-sized, radially symmetric molecules with well-defined, homogeneous, and monodisperse structure consisting of tree-like arms or branches [1].
What are the types of dendrimers?
2. Types of dendrimers
| Dendrimer types | Application | Drug |
|---|---|---|
| Peptide dendrimer | Gene therapy | DNA |
| Dendronized polypeptide (denpol) dendrimer | siRNA delivery | siRNA |
| Glycodendrimers | Anti-HIV dendritic cell-based immunotherapy | – |
| Polypolypropylene oxide cored PAMAM | Solubility enhancement | Ketoprofen, diflunisal, ibuprofen |
How are dendrimers used in drug delivery?
Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach.
How do dendrimers increase solubility?
As the size of drug particles decreases, the surface area increases leading to higher interaction of the drug particles with the medium; and hence improves the solubility of the compound (Blagden et al., 2007).