What is the treatment for hepatoblastoma?
Treatment for hepatoblastoma is aimed at removing (resecting) as much of the tumor as possible. Liver tissue can regenerate after a portion is removed. Most hepatoblastomas also require treatment with chemotherapy to shrink the tumor before surgery. This makes it easier and safer for the surgeon to remove the mass.
Can hepatoblastoma be cured?
Can hepatoblastoma be cured? Often, healthcare providers can use surgery to remove smaller tumors, eliminating the tumors in your child’s liver and essentially curing the disease.
What is the survival rate of hepatoblastoma?
Hepatoblastoma Prognosis
Survival rates have reached 80-90 percent. This rate depends upon staging at diagnosis. Patients with fully resected tumors have a greater than 85 percent chance of survival. The rate is about 60 percent for those with metastatic disease that responds to chemo.
What is high risk hepatoblastoma?
Only patients who fulfilled the SIOPEL protocol criteria for high-risk hepatoblastoma (defined as tumour involving all 4 liver sectors (PRETEXT IV), vascular invasion, extrahepatic disease, α-fetoprotein (AFP) concentration below 100 ng/ml at diagnosis, or tumour rupture) were included in the analysis.
What are the stages of hepatoblastoma?
Stage I – usually a tumor that can be completely removed with surgery. Stage II – usually a tumor that can mostly be removed by surgery but very small amounts of the cancer are left in the liver. Stage III – usually a tumor that cannot be completely removed and the cancer cells are found in the lymph nodes.
Does hepatoblastoma come back?
Recurrences can occur in 16 percent of children after transplantation. Recurrences are most common during the first two years, and rarely occur thereafter. Hepatoblastoma most commonly spreads to the lungs.
What is Siopel in hepatoblastoma?
International Childhood Liver Tumors Strategy Group (SIOPEL) introduced the concept of preoperative chemotherapy in hepatoblastoma, most common malignant liver tumor in children. This required introduction of the preoperative tumor staging system called PRETEXT.
What causes hepatoblastoma in children?
Although the exact cause of hepatoblastoma is unknown, children who have been born prematurely, are of low birth weight, or who have genetic condition (including but not limited to hemihypertrophy syndromes, Beckwith Weidemann, Trisomy 18, and germline APC gene mutations) are at increased risk of developing …
How common is hepatoblastoma in children?
Hepatoblastoma is the most common liver cancer of childhood, although it affects only 2 to 3 people in a million. It affects children during the first three years of life and usually presents as an abdominal mass which causes pain and discomfort.
What causes hepatoblastoma?
How is hepatoblastoma diagnosed?
Hepatoblastoma is a very rare cancerous (malignant) tumor that starts in the liver. Symptoms include a lump (mass), swelling, or pain in the belly (abdomen). Diagnosis is done with blood tests, imaging, and biopsy. It may be treated with surgery, chemotherapy, and other methods.