What is Virilizing ovarian tumor?
A virilizing ovarian tumor (VOT) is a rare cause of hyperandrogenism in pre- and postmenopausal women. Although transvaginal ultrasound is considered as the first-line imaging method for ovarian tumors, it is examiner-dependent.
What is a Virilizing syndrome?
Virilization is a condition in which a female develops characteristics associated with male hormones (androgens), or when a newborn has characteristics of male hormone exposure at birth.
What causes virilization in females?
Virilization is caused by excess production of androgens usually because of a tumor in or enlargement of an adrenal gland or a tumor in an ovary or abnormal hormone production by the ovaries.
Which is masculinizing tumor of the ovary?
MASCULINOVOBLASTOMA: PRIMARY MASCULINIZING TUMOR OF THE OVARY ( SO-CALLED LARGE CELL VARIETY—HYPERNEPHROID—LUTEOMA ) | JAMA Internal Medicine | JAMA Network.
What is Arrhenoblastoma?
Listen to pronunciation. (uh-REE-noh-blas-TOH-muh) A rare type of ovarian tumor in which the tumor cells secrete a male sex hormone. This may cause virilization (the appearance of male physical characteristics in females).
What is Sertoli Leydig cell tumor?
Sertoli-Leydig cell tumor (SLCT) is a rare cancer of the ovaries. The cancer cells produce and release a male sex hormone called testosterone.
What is the main characteristics of Virilism?
Symptoms of Virilization
Symptoms depend on the sex and age of the person affected. Symptoms of virilization include excess facial and body hair (hirsutism), baldness, acne, deepening of the voice, increased muscularity, and an increased sex drive.
What is the difference between hirsutism and virilization?
Abstract. Hirsutism is the medical term that refers to the presence of excessive terminal (coarse) hair in androgen-sensitive areas of the female body (upper lip, chin, chest, back, abdomen, arms, and thighs). Virilization is more extensive than hirsutism with additional evidence of masculinization.
Does PCOS have virilization?
Extremely high androgen levels, such as when a tumor is present, may cause male-like balding, deepening of the voice, increased muscle mass, enlargement of the clitoris, and decreased breast size. These effects of excess androgens are called virilization, occur rarely, and typically are not seen with PCOS.
Can PCOS cause virilization?
Thanks to many protective mechanisms, maternal virilization during pregnancy is uncommon. PCOS is the major cause of hirsutism in women, but is rarely responsible on its own for a maternal virilization during pregnancy [3].
Is Gonadoblastoma malignant?
Gonadoblastoma is a rare benign tumor that has the potential for malignant transformation and affects a subset of patients with an intersex disorder or disorder of sex development (DSD).
What is Seminomatous tumor?
Seminoma is a malignant germ cell tumor that involves most commonly the testicle or less frequently the mediastinum, the retroperitoneum, or other extra-gonadal sites. It is one of the treatable and curable cancers, with a survival rate of over 95% if discovered in early stages.[1][2][3][4]
Can females have Sertoli-Leydig tumors?
This type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. Sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. While they can be found in women of all age groups, they are most common in young women.
Are Sertoli-Leydig cell tumor benign or malignant?
Sertoli-Leydig Cell Tumors (SLCTs), also known as arrhenoblastomas, make up <0.5–1% of all ovarian tumors and are benign or malignant, androgen-secreting tumors originating from the ovarian stromal sex cords [1].
What causes virilization?
The direct cause of virilization is the production of too much male hormone (androgens) in the body. This excess hormone production has many possible causes, including: Use of anabolic steroids, uncommon among women. Medications.
What is the difference between hirsutism and Virilism?
Hirsutism is the medical term that refers to the presence of excessive terminal (coarse) hair in androgen-sensitive areas of the female body (upper lip, chin, chest, back, abdomen, arms, and thighs). Virilization is more extensive than hirsutism with additional evidence of masculinization.
What are the main characteristics of virilism?
Virilization is a condition in which women develop male-pattern hair growth and other masculine physical traits. Women with virilization often have an imbalance in their sex hormones, including male sex hormones such as testosterone. Male sex hormones are also known as androgens.
Is Metformin good for polycystic ovaries?
Metformin works as a treatment for PCOS by enhancing the body’s sensitivity to insulin. This decreases the levels of circulating insulin and also produces a positive effect on adipose (fat) tissue. Doctors traditionally recommend metformin as a PCOS treatment for women who have a raised BMI (body mass index).
What are the main characteristics of Virilism?
Virilization can occur in childhood in both males and females due to excessive amounts of androgens. Typical effects of virilization in children are pubic hair, accelerated growth and bone maturation, increased muscle strength, acne, and adult body odor.
What causes Gonadoblastoma?
Risk factors. Gonadoblastoma is most often associated with an abnormal chromosomal karyotype, gonadal dysgenesis, or the presence of a Y chromosome in over 90% of cases.
Is Gonadoblastoma a germ cell tumor?
Gonadoblastoma. Gonadoblastoma is a mixed germ cell tumor with undifferentiated cells and is most frequently observed in female children, 1/3 of whom are younger than 15 years of age. This tumor was first described by Scully (20).
What is the difference between seminomas and Nonseminomas?
Seminomas are very sensitive to radiation therapy. Nonseminoma: This more common type of testicular cancer tends to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to these different cell types: Choriocarcinoma (rare)
What is the difference between seminomas and Nonseminomas quizlet?
What are the differences between these two types? Seminomas Occur in 30 – 60 year olds and are slow growing. Nonseminomas Occur in late teens to early 40s and are more aggressive and resistant to radiation.
Are Sertoli Leydig tumors malignant?
Sertoli-Leydig Cell Tumors (SLCTs) make up <1% of all ovarian tumors and are benign or malignant, androgen-secreting tumors. Rhabdomyosarcoma (RMS) is a heterogeneous group of malignant tumors that resemble developing skeletal muscle.
Are Sertoli Leydig tumors benign?
Sertoli – Leydig cell tumors (SLCTs) are sex-cord stromal tumors that account less than 0.5 % of primary ovarian neoplasms. They are mostly benign and occur in reproductive age women.