Are smudge cells lymphocytes?
Smudge cells, or basket cells, are remnants of leukocytes. They have no cytoplasm, and sometimes all that can be seen are smashed nuclei. Smudge cells are formed from leukocytes, typically lymphocytes, that are fragile, and are destroyed or smudged in the physical process of making a smear.
What leukemia has smudge cells?
Chronic lymphocytic leukemia (CLL) is the most commonly encountered leukemia in the clinical laboratory. Cytoskeletal defects in CLL lymphocytes can result in the formation of up to 75% smudge cells (SCs) during blood film preparation.
Can an infection cause smudge cells?
Abstract. The smudge cells are well studied as a prognostic factor for chronic lymphocytic leukemia, but it is also found in viral infections. We experienced a case of abnormal hyperleukocytosis (WBC 41,600/mm3) associated with infectious mononucleosis (IM).
Are smudge cells a sign of lymphoproliferative disorders?
If the Smudge Cells along with the absolute lymphocytes continue to rise, then the odds of a lymphoproliferative disorder such as CCL would be present. (6) Dr. Susan J. Leclair, PhD, CLS (NCA) – Boston, Massachusetts; Explaination of Lymphocytes; Retrieved from: [email protected]
What are smudge cells?
The image above presents the clear appearance of Smudge Cells on the left side, which are the clumped up cells that are Violet in color. Don’t get mistaken by the three dark violet colored cells that are in the middle because they are small mature-looking lymphocytes, and on the center is a condensed nuclear chromatin.
Do smudge cells predict shortened OS in chronic lymphocytic leukemia (CLL)?
In the current study, we demonstrate that a low percentage of smudge cells predicts shortened OS as both a continuous and categoric variable in an independent sample of CLL patients participating in a prospective observational cohort study.
What is the survival rate of patients with smudge cells?
Additionally, it was seemingly that patients with smudge cells of 50% or more had a lower survival rate than those with smudge cells less than 50% in all cancers with follow-up at 2-month intervals, but without statistical significance (P=0.064).