How do you administer streptokinase?
An initial dose of 250 000 IU streptokinase should be infused into a peripheral vein over 30 minutes. A maintenance infusion of 100 000 IU/hour for 72 hours should follow. Infuse 1 500 000 IU streptokinase into a peripheral vein preferably over a short time of 1-2 hours.
What is streptokinase used to treat?
Streptokinase is used to dissolve blood clots that have formed in the blood vessels. It is used immediately after symptoms of a heart attack occur to improve patient survival. This medicine may also be used to treat blood clots in the lungs (pulmonary embolism) and in the legs (deep venous thrombosis) .
When should streptokinase be administered?
Streptokinase treatment should be initiated as soon as possible after thrombotic event onset, preferably within 7 days. The loading dose is recommended to neutralize any anti-streptokinase antibodies which may be present.
Why is streptokinase only given once?
The report also says that streptokinase should not be given twice because of the formation of anti-streptokinase antibodies. We found that almost all patients had low titres of anti-streptokinase antibodies before thrombolysis; they increased rapidly after treatment but then started to fall.
How do you give a SK injection?
Instill 250,000 IU Streptokinase in 2 mL of solution into each occluded limb of the cannula slowly. Clamp off cannula limb(s) for 2 hours. Observe the patient closely for possible adverse effects. After treatment, aspirate contents of infused cannula limb(s), flush with saline, reconnect cannula.
Where is streptokinase injected?
As a medication it is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism. The type of heart attack it is used in is an ST elevation myocardial infarction (STEMI). It is given by injection into a vein.
What are the side effects of streptokinase?
Common side effects of Streptase (streptokinase) include:
- nausea,
- headache,
- dizziness,
- low blood pressure,
- mild fever,
- bleeding from wounds or gums,
- rash,
- itching,
What are the disadvantages of streptokinase?
Despite the mortality benefits of streptokinase in AMI patients, it includes some adverse reactions such as allergic reactions, hypotension, and bleeding. Streptokinase is a non-human protein, and its presentation into the circulatory system can lead to severe anaphylactic responses including death (6, 7).
Why streptokinase should be administered within 12 hours?
Thus, ‘accelerated’ streptokinase given over 15 minutes in patients presenting within 12 hours of acute myocardial infarction is well tolerated and results in higher grades of TIMI flow in the infarct-related artery as compared to the “conventional” one-hour infusion regimen.
Why streptokinase is not used in second time?
Medical uses
As streptokinase is a bacterial product, the body has the ability to build up an immunity to it. Therefore, it is recommended that this medication should not be used again after four days from the first administration, as it may not be as effective and can also cause an allergic reaction.
Why is streptokinase not used?
Although much less expensive, this makes Streptokinase a less attractive agent for acute treatments in ischemic stroke than tPA products. Studies of streptokinase in acute stroke were stopped due to an increase in mortality compared to placebo due to increased haemorrhage rates.
Is streptokinase still used?
Currently, despite the wide use of tissue plasminogen activator in developed nations, streptokinase remains essential to the management of acute myocardial infarction in developing nations.
What is the major side effect of streptokinase?
flushing, muscle or bone pain, shivering, and. allergic reactions.
Which is the antidote for streptokinase?
Drugs that can reverse effects of streptokinase include aminocaproic acid, aprotinin, and tranexamic acid.
Can we repeat streptokinase?
Repeat treatment with streptokinase administered more than 5 days and less than 12 months after initial treatment may not be effective. This is because of the increased likelihood of resistance due to antistreptokinase antibodies.