How IEDB is assisting the epitope mapping?
The IEDB-AR homology mapping tool provides the mapping of a linear epitope from a source protein to the proteins with known 3D structures by sequence similarity search of the epitope source sequence against protein sequences in the Protein Data Bank (PDB) (26).
What is BepiPred?
Description: BepiPred predicts the location of linear B-cell epitopes using a combination of a hidden Markov model and a propensity scale method.
What is population coverage analysis?
Population coverage analysis tool calculates the fraction of individuals predicted to respond to a given set of epitopes with known MHC restrictions.
What is B-cell epitope?
B-cell epitopes can be defined as a surface accessible clusters of amino acids, which are recognized by secreted antibodies or B-cell receptors and are able to elicit cellular or humoral immune response [1].
How do you calculate population coverage?
The allele frequencies were calculated by estimating the total number of copies of alleles (a) and the number of subjects (n) in each group of populations and using the formula, AF = a/2n.
Why is epitope mapping important?
Epitope mapping has been crucial to the development of vaccines against prevalent or deadly viral pathogens, such as chikungunya, dengue, Ebola, and Zika viruses, by determining the antigenic elements (epitopes) that confer long-lasting immunization effects.
What is difference between antigenicity and immunogenicity?
The term immunogenicity refers to the ability of a substance to induce cellular and humoral immune response, while antigenicity is the ability to be specifically recognized by the antibodies generated as a result of the immune response to the given substance.
What is catchment population?
Catchment population is the estimate of the population served by a hospital or other health service unit or facility; it is the population in the catchment area. European Observatory on Health Systems and Policies.
What is an epitope example?
Common epitopes used for this purpose are Myc-tag, HA-tag, FLAG-tag, GST-tag, 6xHis, V5-tag and OLLAS. Peptides can also be bound by proteins that form covalent bonds to the peptide, allowing irreversible immobilisation.