What are different types of giant cells?
Types include foreign-body giant cell, Langhans giant cell, Touton giant cells, Giant-cell arteritis, and Reed–Sternberg cell.
What are the different types of giant cell lesions?
Central giant cell granuloma. Giant cell tumor of bone. Aneurismal bone cyst. Cherubism.
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Where giant cells are present in the concerned background and are pathognomic:
- Hodgkin’s syndrome.
- Peripheral giant cell granuloma.
- Giant cell fibroma.
What are giant cells called?
In giant-cell tumours of bone and tendon the cells have many nuclei crowded together. The megakaryocytes, the normal bone-marrow cells thought to be the source of the blood platelets, are also called giant cells.
What are Touton type giant cells?
Touton giant cells are a type of multinucleated giant cell seen in lesions with high lipid content such as fat necrosis, xanthoma, and xanthelasma and xanthogranulomas. They are also found in dermatofibroma.
What is the function of giant cells?
Foreign body giant cells (FBGC) most commonly are observed at the tissue/material interface of implanted medical devices, prostheses, and biomaterials (**2). In this context, adherent macrophages and foreign body giant cells constitute the foreign body reaction (Figure 1).
What are rare giant cells?
A giant cell tumor is a rare, aggressive non-cancerous tumor. It usually develops near a joint at the end of the bone. Most occur in the long bones of the legs and arms. Giant cell tumors most often occur in young adults when skeletal bone growth is complete. The exact cause of giant cell tumors remains unknown.
What are giant cell tumors?
What is central giant cell granuloma?
Central giant cell granuloma (CGCG) is an uncommon, histologically benign but locally aggressive and destructive osteolytic lesion of osteoclastic origin that occurs in the craniofacial region, especially in jaw bones.[1] It is a solitary lesion, presenting radiographically as a multilocular radiolucency with scalloped …
What are osteoclastic giant cells?
Osteoclastic giant cell tumors (OGCT) resemble benign-appearing giant cell tumors of bone, and contain osteoclast-like multinucleated cells and mononuclear cells. The histogenesis of OGCT is controversial, with a suggestion of both epithelial and mesenchymal origin.
Why are giant cells multinucleated?
MULTINUCLEATED giant cells (MGC) are a common feature of granulomas that develop during certain infections, the most prominent example being tuberculosis, or as a consequence of foreign body reactions.
Is giant cell malignant?
Most giant cell tumors occur at the ends of the long bones of the arms and legs, near a joint (such as the knee, wrist, hip, or shoulder). Most are benign (not cancer) but some are malignant (cancer).
What is giant cell carcinoma?
Giant cell carcinoma is a variant of sarcomatoid carcinoma characterized by the presence of numerous multinucleated malignant tumor cells (Fig. 22-40). These tumor cells have large nuclei with prominent nucleoli.
What are giant cells that destroy bone?
Osteoclasts are giant cells containing between 10 and 20 nuclei. They closely attach to the bone matrix by binding its surface integrins to a bone protein called vitronectin.
What is multinucleated giant cells?
Multinucleated giant cells (MNGCs) are a special class of giant cell formed by the fusion of monocytes/macrophages abundantly found in human tissues.
What is giant cell fibroma?
Giant-cell fibroma is a type of fibroma not associated with trauma or irritation. It can occur at any age and on a mucous membrane surface. The most common oral locations are on the gingiva of the mandible, tongue, and palate. It is a localized reactive proliferation of fibrous connective tissue.
What is multinucleated giant cell?
Can giant cell tumor spread?
They occur slightly more often in females. While giant cell tumors are typically benign (noncancerous), they can grow quickly and destroy bone close to a joint. In rare cases, a giant cell tumor may spread, or metastasize, to the lungs.
Can giant cell tumor be cured?
The goal for treatment of a giant cell tumor is to remove the tumor and prevent damage to the affected bone. Tumors that can’t be removed surgically can often be controlled and sometimes destroyed with radiation therapy. Giant cell tumors can come back.
What is a rare giant cell?
A giant cell tumor is a rare, aggressive non-cancerous tumor. It usually develops near a joint at the end of the bone. Most occur in the long bones of the legs and arms. Giant cell tumors most often occur in young adults when skeletal bone growth is complete.
How are giant cells formed?
Giant cells are formed by fusion of various cells such as macrophage, epithelioid cells, monocytes, etc., These are multi-nucleated,[1] large in size, and most of the times present at the site of chronic inflammation and other granulomatous conditions.
What is giant cell tumor of bone?
What is a giant cell tumor? Giant cell tumor of bone is a rare, aggressive non-cancerous tumor. It generally happens in adults between ages 20 and 40 when skeletal bone growth is complete. It usually develops near a joint at the end of the bone.
Is giant cell tumor curable?
Can giant cell tumor metastasis lung?
Metastasis in giant cell tumor (GCT) of bone occurs most commonly in the lung, variously reported from 1% to 9% [7, 9, 17, 19, 20]. There have been isolated case reports of its occurrence at different sites, such as the lymph nodes (mediastinum, paraaortic), bone, skin, and breast [1, 6, 9, 13, 14, 21].
What is the best treatment for giant cell tumor?
Surgical Treatment
Surgery has proven to be the most effective treatment for giant cell tumors. Surgical treatment may include: Curettage. Curettage is the surgical procedure most commonly used to treat giant cell tumors.
How is giant cell tumor treated?
Although giant cell tumors are not cancerous, they are aggressive and can destroy the surrounding bone. Treatment for a giant cell tumor almost always involves surgery to remove the tumor and prevent damage to the bone near the affected joint.