What is the major side effect of phenytoin?
Headache, nausea, vomiting, constipation, dizziness, feeling of spinning, drowsiness, trouble sleeping, or nervousness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Phenytoin may cause swelling and bleeding of the gums.
What are the side effects of pentobarbital?
Common side effects of pentobarbital include:
- Skin swelling (rare)
- Slow heart rate.
- Low blood pressure (hypotension)
- Agitation.
- Loss of balance or coordination.
- Central nervous system (CNS) depression.
- Confusion.
- Dizziness.
Can you take PHENobarbital and phenytoin together?
phenytoin PHENobarbital
Using phenytoin together with PHENobarbital may affect your seizure control. You may need dose adjustments or special tests in order to safely take both medications together. This combination may alter phenytoin levels.
What is the most common side effect of PHENobarbital?
The most common side effect of phenobarbital is sleepiness or fatigue. Be careful with driving, operating machinery, or any other dangerous activity until you know how you react to phenobarbital. Other side effects include: depression.
What are the long term side effects of phenobarbital?
Long-term Effects
- Moodiness/irritability.
- Confusion.
- Insomnia.
- Impaired judgment.
- Memory problems.
- Increased aggression.
- Blistering on the extremities.
What drugs should not be taken with phenytoin?
Drugs whose efficacy is impaired by phenytoin include: corticosteroids, coumarin anticoagulants, digitoxin, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, theophylline, vitamin D.
What does phenobarbital do to the brain?
Phenobarbital slows the activity of your brain and nervous system. Phenobarbital is used to treat or prevent seizures. Phenobarbital is also used short-term as a sedative to help you relax.
Why is phenobarbital used with phenytoin?
PHENOBARBITAL+PHENYTOIN contains two antiepileptic/anticonvulsant medicines, namely: ‘Phenobarbital’ and ‘Phenytoin. ‘ It is used to control seizures (fits) in epilepsy. PHENOBARBITAL+PHENYTOIN also controls or prevents seizures during/after brain surgery and treats trigeminal neuralgia (facial nerve pain).
Is phenytoin and phenobarbital the same?
Phenobarbital and phenytoin are equally but incompletely effective as anticonvulsants in neonates. With either drug given alone, the seizures were controlled in fewer than half of the neonates.
What are some common problems with those on phenobarbital?
Common side effects of phenobarbital include:
- dizziness,
- drowsiness,
- problems with memory or concentration,
- excitation,
- irritability,
- aggression,
- confusion (especially in children or older adults);
- loss of balance or coordination,
What are the long-term side effects of phenobarbital?
What drugs does phenytoin interact with?
Drugs Affected By Phenytoin
| Interacting Agent | Examples |
|---|---|
| Other | Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D |
| Drugs whose level is decreased by phenytoin |
What causes phenytoin toxicity?
Phenytoin toxicity can occur from an increase in the daily dose of phenytoin, changes in the formulations or brands as well as changes in the frequency of administration. It can also occur when patients are started on new medications that interact with the metabolism or binding capacity of phenytoin to plasma proteins.
What is the difference between phenytoin and phenobarbital?
The chief side effect of phenobarbital is drowsiness, which is usually associated with overdosage. Phenytoin, on the other hand, causes gingival hyperplasia in many patients, irreversible hypertrichosis in some patients and lethal reactions, such as Stevens-Johnson syndrome, in a few patients.
Is phenytoin sodium the same as phenobarbital?
Is phenytoin the same as phenobarbital?
What are the signs and symptoms of phenytoin toxicity?
Symptoms of a phenytoin overdose may include:
- Coma.
- Confusion.
- Seizures (occasionally)
- Dizziness.
- Fever.
- Low blood pressure.
- Muscle rigidity or spasms.
- Sleepiness.
Does phenytoin cause sedation?
Side effects of phenytoin include sedation, a cerebellar syndrome, phenytoin encephalopathy, psychosis, locomotor dysfunction, hyperkinesia, megaloblastic anemia, decreased serum folate level, decreased bone mineral content, liver disease, IgA deficiency, gingival hyperplasia, and a lupus-like hypersensitivity syndrome …
What is the antidote for phenytoin?
There is no antidote, and there is no evidence that any method of gastrointestinal decontamination or enhanced elimination improves outcome.
Can phenobarbital cause brain damage?
Especially susceptible to the neurotoxic effects of phenytoin are epileptic children with severe brain damage who are on multiple drugs. In those children, balance disturbance may develop and be followed by gradual loss of locomotion.
What is toxic level of phenytoin?
Toxic phenytoin levels are defined as greater than 30 µg/mL. Lethal levels are defined as greater than 100 µg/mL. The reference range of free phenytoin is 1-2.5 µg/mL. In patients with renal failure associated with hypoalbuminemia, free phenytoin levels may be more accurate than total phenytoin levels.
Does phenobarbital affect memory?
With phenobarbital, there is a high risk for serious cognitive effects impacting attention and memory.
Can phenytoin cause brain damage?
Does phenytoin cause memory loss?
Antiseizure drugs
All drugs that depress signaling in the CNS can cause memory loss. Alternatives: Many patients with seizures do well on phenytoin (Dilantin), which has little if any impact on memory.
Does phenytoin cause brain damage?