What is the meaning of dendrimers?
Dendrimers are highly defined artificial macromolecules, which are characterized by a combination of a high number of functional groups and a compact molecular structure [17]. The emerging role of dendritic macromolecules for anticancer therapies and diagnostic imaging is remarkable.
What are dendrimers used for?
Due to their size, dendrimers are used in nanomedicine research. They are found to be useful as delivery or carrier systems for drugs and genes, but studies have shown that some dendrimers have medicinal uses of their own, mostly due to their antifungal, antibacterial and cytotoxic properties [5,6].
How do dendrimers work drug delivery?
Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach.
What are the types of dendrimers?
2. Types of dendrimers
| Dendrimer types | Application | Drug |
|---|---|---|
| Peptide dendrimer | Gene therapy | DNA |
| Dendronized polypeptide (denpol) dendrimer | siRNA delivery | siRNA |
| Glycodendrimers | Anti-HIV dendritic cell-based immunotherapy | – |
| Polypolypropylene oxide cored PAMAM | Solubility enhancement | Ketoprofen, diflunisal, ibuprofen |
Which is the example of dendrimer?
Examples of several types of dendrimers include those which have immense applications in drug delivery including poly(amidoamine) (PAMAM) dendrimers, poly(propylene imine) (PPI) dendrimers, polyether-copolyester (PEPE) dendrimers, PEGylated dendrimers, peptide dendrimers, etc.
How is dendrimer different from a polymer?
Dendrimers are hyperbranched macromolecules having a perfectly defined and highly functionalized repetitive structure. In contrast to all the other types of polymers, they are not synthesized by polymerization reactions but step by step (‘layer after layer’), which allows a perfect control of their structure.
How do dendrimers increase solubility?
As the size of drug particles decreases, the surface area increases leading to higher interaction of the drug particles with the medium; and hence improves the solubility of the compound (Blagden et al., 2007).
What are some desirable features of dendrimers for drug delivery?
[23] Unlike traditional polymers, dendrimers have received considerable attention in biological applications due to their high water solubility,[24] biocompatibility,[25] polyvalency[12] and precise molecular weight. [26] These features make them an ideal carrier for drug delivery and targeting applications.
What are dendrimers Slideshare?
Dendrimer Polymers techniques is a controlled release system which helps to s… IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research…
Are dendrimers hydrophobic?
The internal architecture of a dendrimer is usually hydrophobic due to hydrophobic interactions and hydrogen bond formations and is suitable for encapsulating hydrophobic drugs/bio-actives (Medina and El-Sayed, 2009).