Can I use acyclovir while breastfeeding?
Breastfeeding and cold sores
Aciclovir cream, aciclovir or valaciclovir tablets are all considered safe while breastfeeding. 3 Outbreaks however, may require treatment with tablets rather than cream.
Is acyclovir harmful during pregnancy?
Conclusion: Use of acyclovir in the first trimester does not increase birth defects, and it should be the antiviral drug of choice in early pregnancy.
Can you take antiviral medication while breastfeeding?
Although doses being used in some studies for COVID-19 have been >40 mg/day, famotidine is a safe drug that is given directly to newborn infants in higher dosages than are transmitted in breast milk, so it would not be expected to cause any adverse effects in breastfed infants.
What should I monitor with acyclovir?
Consider monitoring renal function. Possible increased incidence of adverse CNS effects (coma, confusion, hallucinations, somnolence), GI effects (nausea, vomiting), or dizziness during oral acyclovir therapy compared with younger adults.
Is valacyclovir safe while breastfeeding?
Safe During Breastfeeding
A small amount of oral valacyclovir will pass to baby during breastfeeding, but the American Academy of Pediatrics supports use of the drug while breastfeeding as no side effects have been reported.
Does acyclovir pass through placenta?
The cord-to-maternal plasma concentration of acyclovir has been reported to be around 1.3,95,96 indicating that acyclovir readily crosses the placental barrier. The fetal transfer of acyclovir from maternal circulation was observed to be nonsaturable in perfused human term placenta.
How long does acyclovir stay in breastmilk?
A woman who was 6 weeks postpartum received intravenous acyclovir 300 mg (5 mg/kg) three times daily for 5 days. Milk samples were taken every 6 hours after the last dose. The peak level was 7.3 mg/L and the drug was detectable in milk for up to 88 hours after the last dose.
Can I breastfeed if I have cold sore?
If you have cold sores, it is safe to breastfeed your baby as long as the cold sores are not on the breast or nipple. If they are, it may be wise to breastfeed from the unaffected nipple only until the lesions have cleared up. You would express and dispose of breastmilk from the affected nipple.
What are common side effects of acyclovir?
Acyclovir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- upset stomach.
- vomiting.
- diarrhea.
- dizziness.
- tiredness.
- agitation.
- pain, especially in the joints.
- hair loss.
Why is acyclovir selectively toxic?
Further selective toxicity is derived from the fact that acyclovir triphosphate is selectively taken up by viral α-DNA polymerases because its structure resembles that of the essential DNA precursor, 2′-deoxyguanosine triphosphate.
How long is valacyclovir in breastmilk?
The median half-life in milk was 2.1 hours (range 1.3 to 12.2 hours). [3] Using the median milk levels from this study, an exclusively breastfed infant would receive 0.34 mg/kg daily by mouth with this regimen, which is less than 1% of dosage given to neonates.
How much acyclovir is safe during pregnancy?
Both the American College of Obstetricians and Gynecologists and the Centers for Disease Control and Prevention recommend the following dosages during pregnancy: acyclovir: 400-mg doses three times per day. valacyclovir: 500-mg doses twice per day.
Is it safe to take valacyclovir while breastfeeding?
Can I breastfeed while taking valacyclovir?
What if someone with a cold sore kissed my baby?
The virus spreads through saliva or skin-to-skin contact or by touching an object that was handled by someone infected with the virus. “If you have a cold sore, don’t kiss the baby because it can definitely be transmitted to their skin,” says Roxanne MacKnight, a family physician in Miramichi, NB.
Who should not take acyclovir?
Who should not take Acyclovir?
- dehydration.
- chronic kidney disease stage 3B (moderate)
- chronic kidney disease stage 4 (severe)
- chronic kidney disease stage 5 (failure)
- kidney disease with likely reduction in kidney function.
Is acyclovir safe for babies?
Acyclovir is used to treat herpes simplex virus (HSV) disease in infants. Treatment with high dose acyclovir, 60 mg/kg/day, is recommended; however, the safety of this dosage has not been assessed in the past 15 years, and this dosage is not currently approved for infants by the US Food and Drug Administration.
How toxic is acyclovir?
In general, acyclovir seems to have a low toxic potential. Data from available investigations do not give support for a mutagen, teratogen or carcinogen hazard in patients receiving recommended clinical doses.
How is acyclovir excreted from the body?
Acyclovir is eliminated from the body primarily by urinary excretion of unchanged drug. Renal clearance of acyclovir (C/r) is usually two to three times greater than glomerular filtration, indicating that a tubular secretory mechanism plays an important role in the drug’s renal elimination.
Will Valtrex hurt my milk supply?
The American Academy of Pediatrics considers acyclovir to be safe during breastfeeding, according to the researchers. And the current study, the researchers say, confirms that Valtrex is not found in breast milk. They conclude that Valtrex is safe during breastfeeding.
How much acyclovir should I take for a cold sore?
For treatment of cold sores: Adults—2000 milligrams (mg) every 12 hours for one day. Children 12 years of age and above—2000 milligrams (mg) every 12 hours for one day. Children below 12 years of age—Use and dose must be determined by your doctor.
What if mom has cold sore with newborn?
After birth
You should not kiss a baby if you have a cold sore to reduce the risk of spreading infection. Cold sores and other blisters caused by the herpes virus are at their most contagious when they burst. They remain contagious until completely healed.
Can I breastfeed if my baby has a cold sore?
A mother may breastfeed her infant or express milk from the unaffected breast but should ensure that the lesions on the affected breast are completely covered to avoid transmission. Mothers should also follow appropriate hand hygiene practices to avoid transmission of herpes to her infant.
What is the most common side effect of acyclovir?
The most frequent adverse reactions associated with the use of ZOVIRAX® (acyclovir) are headache and nausea. Neurological side effects have also been reported in rare instances. Elderly patients and patients with a history of renal impairment are at increased risk of developing these effects.
Why do you have to drink water with acyclovir?
Getting the most from your treatment
You should drink plenty while you are on aciclovir to keep your kidneys working well. Drinking water is best, but hot drinks and non-alcoholic cold drinks are also suitable. Aciclovir could cause your skin to become more sensitive to sunlight than it is usually.