Does alcohol affect theophylline?
Theophylline is metabolised in the liver. The plasma-theophylline concentration is increased in heart failure, hepatic impairment, and in viral infections. The plasma-theophylline concentration is decreased in smokers, and by alcohol consumption.
What should you avoid when taking theophylline?
theophylline Caffeine
Avoid drinks or foods that contain caffeine, such as coffee, tea, cola, and chocolate. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs.
What does theophylline interact with?
| Drug | Type of interaction |
|---|---|
| Alcohol | A single large dose of alcohol (3 ml/kg of whiskey) decreases theophylline clearance for up to 24 hours |
| Allopurinol | Decreases theophylline clearance at allopurinol doses ≥600 mg/day |
| Aminoglutethimide | Increases theophylline clearance by induction of microsomal enzyme activity |
Can you drink coffee with theophylline?
Patients taking theophylline should avoid medications containing caffeine when possible. Patients may also need to limit their intake of caffeine-containing beverages or foods (e.g., coffee, green tea, other teas, colas, or chocolate) to avoid caffeine-like side effects.
Why is theophylline no longer used?
Oral theophylline has been used as a bronchodilator to treat chronic obstructive pulmonary disease (COPD) for decades, but it has fallen out of favor due to the side effects that come with the higher doses that are required to achieve any beneficial effect, as well as the advancement of improved drug treatment.
What can affect theophylline levels?
Administration of allopurinol, oral contraceptives, cimetidine, erythromycin, quinolone antibiotics, fluvoxamine, zileuton, and zafirlukast has been shown to increase theophylline levels.
What does theophylline do for your lungs?
Theophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.
Does theophylline cause weight gain?
After intranasal theophylline eight patients improved their smell function further, improved their ability to perceive food flavor better and gained an additional 4.5±1.4 lbs over that gained on oral theophylline.
What are the signs and symptoms of theophylline toxicity?
What happens to patients with theophylline intoxication? Signs of mild theophylline toxicity are nausea, vomiting, abdominal pain, tachycardia, and muscle tremor and are usually seen with levels around 20 to 25 mg/L.
Can you drink alcohol while taking Uniphyllin?
Alcohol can alter the way these tablets work. Please consult your doctor if you intend to drink alcohol whilst taking these tablets. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
What are the long-term side effects of theophylline?
Many of the typical symptoms of theophylline toxicity are non-specific, which further perpetuates the challenges of recognition in a long-term user. These include nausea, vomiting, fatigue, tachycardia and central nervous system (CNS) effects such as dizziness and seizures [3].
What are the early signs of theophylline toxicity?
What happens when you stop taking theophylline?
Withdrawal of theophylline therapy resulted in significant (p < 0.05) deterioration in lung function, exercise performance, and two indices of overall dyspnea, and a significant increase in scoring of symptoms and auscultation findings.
Can you stop theophylline abruptly?
Do not stop or change the dose of this medicine without checking first with your doctor. Before you have any medical tests, tell the medical doctor in charge that you or your child are using this medicine. The results of some tests may be affected by this medicine.
How long does theophylline last in the body?
Theophylline is a long-acting bronchodilator. It provides relief over six to 24 hours. Other types of bronchodilators may be short-acting.
What are the long term side effects of theophylline?