How much Reglan can I take at once?
Adults—At first, 10 milligrams (mg) four times a day, taken 30 minutes before each meal and at bedtime for 2 to 8 weeks. Your doctor may adjust your dose as needed. However, the dose is usually not more than 40 mg. Children—Use and dose must be determined by your doctor.
What is the drug Reglan used for?
This medication is used to treat certain conditions of the stomach and intestines. Metoclopramide is used as a short-term treatment (4 to 12 weeks) for ongoing heartburn when the usual medicines do not work well enough. It is used mostly for heartburn that occurs after a meal or during the daytime.
What is the most serious side effect of Reglan?
REGLAN can cause serious side effects, including: Abnormal muscle movements called tardive dyskinesia (TD). These movements happen mostly in the face muscles. You can not control these movements.
How often can you get IV Reglan?
Intravenous infusions should be made slowly over a period of not less than 15 minutes, 30 minutes before beginning cancer chemotherapy and repeated every 2 hours for two doses, then every 3 hours for three doses.
How quickly does Reglan work?
Metoclopramide (Reglan) typically begins to work in 30 minutes, so it’s best when you time it with your meals. Taking metoclopramide (Reglan) at bedtime will also help relieve any worsening symptoms, since the muscle movements in your gut normally slows down at night.
Will Reglan make you sleepy?
Reglan (metoclopramide) is prescribed for gastrointestinal disorders. The most common side effects of the drug are relatively minor and include restlessness, drowsiness, fatigue and a general lack of energy.
What symptoms does Reglan treat?
Reglan (metoclopramide) is a dopamine antagonist that is used as an antiemetic (anti-vomiting) agent used to treat nausea, vomiting, loss of appetite, heartburn and early satiety (feeling of fullness). Reglan is available in generic form.
Does Reglan make you sleepy?
Why was Reglan taken off the market?
FDA Requires Black Box Warning for Reglan
This led to the FDA requiring a black-box warning in 2009. The warning advises patients about the dangers of developing tardive dyskinesia after long-term use of Reglan and its generic counterparts.
Who should not take Reglan?
Due to the risk of TD, patients should avoid using the drug for longer than 12 weeks and elderly patients should consider a reduced dosage. Reglan should not be used in patients with a history of TD or patients receiving other drugs that are likely to cause the condition. The risk of TD is serious, but it is also rare.
How long does IV Reglan stay in your system?
The mean elimination half-life, clearance, and volume of distribution of metoclopramide were 4.5 hr (range, 2.0 to 12.5 hr), 0.37 L/h/kg (range, 0.10 to 1.24 L/h/kg), and 1.93 L/kg (range, 0.95 to 5.50 L/kg), respectively.
How fast can you push Reglan IV?
However, if severe symptoms are present, therapy should begin with REGLAN Injection (metoclopramide injection) (IM or IV). Doses of 10 mg may be administered slowly by the intravenous route over a 1- to 2-minute period.
Is Reglan a sedating?
Sedation has been reported in reglan® users. Sedation may cause confusion and manifest as oversedation in the elderly (see CLINICAL PHARMACOLOGY, PRECAUTIONS – Information for Patients and ADVERSE REACTIONS – CNS Effects).
Is Reglan a high risk medication?
Use of Reglan, especially for longer than 12 weeks, carries the risk of developing a condition known as tardive dyskinesia (TD), a neurological disorder that involves involuntary, rapid movements of the face and body.
What is a good substitute for Reglan?
At present, the only available alternative to metoclopramide that has been extensively studied in critically ill patients is erythromycin, but both agents are commonly used as a combined strategy to improve gastric emptying and improve patient outcomes [11].