Is sodium thiosulfate present in urine?
Sodium thiosulfate (STS) has a number of uses in medicine, the most well known of which is its role as an antidote for cyanide poisoning. It acts via the conversion of cyanide to the more water-soluble thiocyanate which is readily excreted in urine [1].
What is the function of sodium thiosulfate?
Sodium thiosulfate is an inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio. It has a role as an antidote to cyanide poisoning, a nephroprotective agent and an antifungal drug.
Is sodium thiosulfate antifungal?
Foot baths of sodium thiosulfate are used for prophylaxis of ringworm. It is also used as a topical antifungal agent for tinea versicolor (pityriasis versicolor), possibly in combination with salicylic acid; and for other fungal infections of the skin.
What are the risks of sodium thiosulfate?
Eye: May cause mild eye irritation.
Is sodium thiosulfate safe?
Skin: May cause skin irritation. Ingestion: Ingestion of large amounts may cause gastrointestinal irritation. Inhalation: May cause respiratory tract irritation. Low hazard for usual industrial handling.
Can you touch sodium thiosulfate?
S24/25- Avoid contact with skin and eyes. S28- After contact with skin, wash immediately with plenty of water. S37- Wear suitable gloves. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
What class of drug is sodium thiosulfate?
Classes: Cyanide Antidotes; Extravasation Antidotes.
What are the hazards of sodium thiosulfate?
Danger: oxidisers; skin irritants; cause serious eye irritation; harmful if swallowed; may cause respiratory irritation, allergy or asthma.
How long does it take sodium thiosulfate to work?
Symptomatic relief and clinical improvement may occur within 2 weeks.
Can sodium thiosulfate harm you?
High blood pressure (hypertension) or. Kidney disease or. Liver disease or. Toxemia of pregnancy—Sodium thiosulfate may cause the body to retain (keep) water, which may make these conditions worse.
What is a single dose of sodium thiosulfate?
Administration of one vial constitutes a single dose. Sodium thiosulfate drug product may contain trace impurities of sodium sulfite. The presence of a trace amount of sulfites in this product should not deter administration of the drug for treatment of emergency situations, even if the patient is sulfite-sensitive.
What is another name for sodium thiosulfate?
It is also often called sodium hyposulfite or hypo. Sodium thiosulfate is used in gold mining, water treatment, analytic chemistry, the development of silver -based photographic film and prints, and medicine. The medical uses of sodium thiosulfate include treatment of cyanide poisoning and pityriasis.
What are the side effects of sodium thiosulfate?
Side effects of sodium thiosulfate include: 1 Low blood pressure ( hypotension) (infusion rate-dependent) 2 Nausea /vomiting 3 Disorientation 4 Headache 5 Prolonged bleeding therapy 6 Hypersensitivity reactions 7 Contact dermatitis 8 Warmth 9 Local irritation More
How do you make sodium thiosulfate?
On an industrial scale, sodium thiosulfate is produced chiefly from liquid waste products of sodium sulfide or sulfur dye manufacture. In the laboratory, this salt can be prepared by heating an aqueous solution of sodium sulfite with sulfur or by boiling aqueous sodium hydroxide and sulfur according to this equation: 6 NaOH + 4 S → 2 Na 2S + Na