What class of drug is Procoralan?
Ivabradine is in a class of medications called hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers. It works by slowing the heart rate so the heart can pump more blood through the body each time it beats.
How long does ivabradine stay in your system?
Ivabradine is eliminated with a main half-life of 2 hours (70-75% of the AUC) in plasma and an effective half-life of 11 hours. The total clearance is about 400 ml/min and the renal clearance is about 70 ml/min.
What drugs should not be taken with ivabradine?
Do not use this medicine if you are also using clarithromycin (Biaxin®), itraconazole (Sporanox®), ketoconazole (Nizoral®), nefazodone (Serzone®), nelfinavir (Viracept®), or telithromycin (Ketek®). Using these medicines together may cause serious unwanted effects.
Why is procoralan important?
Ivabradine works by slowing down your heart rate a little. Because your heart is working less quickly, the amount of oxygen your heart needs is reduced.
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About ivabradine.
| Type of medicine | A selective sinus node If inhibitor |
|---|---|
| Used for | To prevent angina pain; heart failure |
| Also called | Procoralan® |
| Available as | Tablets |
What happens if you take too much ivabradine?
Ivabradine overdose results in severe sinus bradycardia with periods of asystole, which can be refractory to atropine. Ivabradine significantly prolongs the sinus node recovery time and QT interval. Dopamine and/or isoproterenol may be effective in the short term to improve heart rate.
What happens if you suddenly stop taking ivabradine?
Tips. Take your ivabradine exactly as directed by your healthcare provider, even if you feel well. Do not suddenly stop taking ivabradine without checking with your healthcare provider first, except if: You are having trouble breathing or difficulty swallowing.
Does ivabradine calm you down?
The researchers believe Ivabradine enhances the cross-talk between the heart and the parasympathetic nerves – calming the system down and returning the autonomic nervous system to a state of “balance”.
Does ivabradine help anxiety?
We conclude that ivabradine showed no undesirable effects on anxiety, locomotion or learning; in fact, some of these parameters were even improved. For the first time it has been shown that ivabradine is a safe cardiovascular drug regarding its effect on psycho-behavioral manifestations.
Does ivabradine make you tired?
Ivabradine can cause serious heart rhythm problems.
Call your doctor at once if you have chest pressure, racing or pounding heartbeats, very slow heartbeats, weakness, tiredness, severe dizziness, or shortness of breath that is worse than usual.
Can ivabradine cause memory loss?
Ivabradine does not impair anxiety-like behavior and memory in both healthy and L-NAME-induced hypertensive rats. Physiol Res.
Can ivabradine help anxiety?