What does Pseudoprogression mean?
Pseudoprogression is a phenomenon in which an initial increase in tumor size is observed or new lesions appear, followed by a decrease in tumor burden; this phenomenon can benefit patients receiving immunotherapy but often leads to premature discontinuation of treatment owing to the false judgment of progression.
What is Pseudoprogression in glioblastoma?
Pseudoprogression (PsP) is a transient magnetic resonance imaging (MRI) pattern mimicking tumor progression but not necessarily accompanied by clinical deterioration. It occurs most frequently during the first 3 months after radiation therapy and improvement will usually occur within a few weeks or months.
What is Hyperprogression?
Hyper-progression (or hyperprogression) is a term that is used to describe the accelerated (more rapid than expected) growth or progression of a cancer after treatment is initiated.
What is irRECIST?
irRECIST (Immune-related Response Evaluation Criteria In Solid Tumors) is a set of published rules that provide better assessment of the effect of immunotherapeutic agents.
What is a pseudo response?
Tumor pseudoresponse, also known just as pseudoresponse, refers to the phenomenon of tumors appearing to respond to a specific treatment on imaging criteria when the lesion actually remains stable or has even progressed.
How long does pseudo progression Last?
Pseudoprogression seems to be associated with a high likelihood of 1-year survival compared to patients experiencing partial response, stable disease or progressive disease in a retrospective analysis conducted on various cancer type.
How do you know if immunotherapy is working?
To see if immunotherapy is effective, your physician (an oncology health provider) must be involved. He or she may order blood tests to check for tumor markers, and he or she may also order scans of the tumor periodically to keep track of it.
What is unequivocal progression?
Definition. An overall level of substantial worsening in non-target disease that is of a magnitude that, even in the presence of SD or PR in target disease, the treating physician would feel it important to change therapy. ( RECIST) [from NCI]
Does immunotherapy get worse before it gets better?
Immunotherapy works differently to chemotherapy. It can sometimes take longer to see results so the cancer may appear to get worse before it gets better. The side effects are different to traditional chemotherapy.
What is a single progression?
This is called “single progression” (of load). Note that by increasing the load, the volume is also increased. When the target repetitions cannot be completed, the load is maintained for the next session, and the repetition targets are attempted again. Reduce the load by 10% if you fail to achieve your target reps in two consecutive workouts.
Should I use intermediate or novice progression rules?
You may have taken some time off from performing an exercise which means you would benefit from changing your progression style from “intermediate” to the novice style temporarily. Therefore, for some exercises in your program you may use novice progression rules, but for others, you may need to use intermediate progression rules.
What is linear progression in weight training?
Linear training, similar to “linear strength,” describes adding the same amount of incremental weight to the load lifted each session. It is more commonly known as linear progression. Which progression system should I choose for exercise X? The line between “compound movement” and “isolation movement” can be a little blurry.
When is it time to change from linear to intermediate progression?
If your progress starts to stall after implementing the deload as described above without a return to progress afterward (assuming sleep, nutrition, etc. are in check), it will be time to consider changing from linear progression to the intermediate progression models.