What does the RET gene do?
The RET gene provides instructions for producing a protein that is involved in signaling within cells.
What does RET mutation stand for?
Structure. RET is an abbreviation for “rearranged during transfection”, as the DNA sequence of this gene was originally found to be rearranged within a 3T3 fibroblast cell line following its transfection with DNA taken from human lymphoma cells.
What is RET in biology?
RET (REarranged during Transfection) is a transmembrane receptor tyrosine kinase that is activated by a complex consisting of a soluble glial cell line-derived neurotrophic factor (GDNF) family ligand (GFL) and a glycosyl phosphatidylinositol-anchored co-receptor, GDNF family receptors alpha (GFRalpha).
What is RET in oncology?
Rearranged during transfection (RET) is an oncogenic driver activated by either RET fusions or mutations. RET fusions occur predominantly in 2% of lung cancers and 10–20% of thyroid cancers and in low frequency in an increasing number of diverse cancers.
How is RET activated?
RET is activated by binding both a soluble ligand (glial cell-line-derived neurotrophic factor; GDNF) and a non-signaling extracellular co-receptor (GDNF family receptor; GFRα). Upon activation of RET, phosphorylation of multiple intracellular tyrosines leads to stimulation of downstream signaling pathways.
Is RET an oncogene?
The RET proto-oncogene was identified as the susceptibility gene for multiple endocrine neoplasia type 2 (MEN 2), an inherited cancer syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma (Pheo), and parathyroid hyperplasia (PTH) (reviewed in Eng, 1999).
Is RET a tumor suppressor gene?
RET is a potential tumor suppressor gene in colorectal cancer.
Is RET a tyrosine kinase?
Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal circumstances interacts with ligand at the cell surface and mediates various essential roles in a variety of cellular processes such as proliferation, differentiation, survival, migration, and metabolism.
Is RET a tumor suppressor?
Expression of RET in normal colon epithelium (brown staining areas) and colon cancer. RET is a receptor tyrosine kinase that is normally involved in signaling processes during embryonic development and contributes to normal function in several types of adult cells.