What is MALT lymphoma?
MALT lymphoma belongs to a group of non-Hodgkin lymphomas called marginal zone lymphomas. It is a low grade (slow growing) non-Hodgkin lymphoma (NHL) that starts in the mucosa which lines some body organs and cavities.
How long can you live with gastric MALT lymphoma?
Survival of Patients With Gastric MALT Lymphoma
The 10-year OS for the entire population was 99.1% ( Figure 2A ), and 10-year OS for stage IE, IIE, and III/IV patients were 99.3%, 100%, and 94.6%, respectively ( Figure 2B ). 10-year OS was better for stage IE patients compared to stage III/IV patients (p=0.002).
Where is MALT found in the body?
Mucosa-associated lymphoid tissue (MALT) is a network of lymphoid cell aggregates and tissue that is distributed in submucosal layers of the gastrointestinal, genital, respiratory, and urinary tracts, as well as in the eyes, skin, thyroid, breasts, tonsils, and salivary glands.
How do you treat MALT?
MALT lymphoma may be treated with the immunotherapy drug rituximab in combination with chemotherapy. This is called chemoimmunotherapy. Commonly used combinations of chemoimmunotherapy include: rituximab with chlorambucil.
Can MALT lymphoma be cured?
Regression of gastric MALT lymphoma can be done in the early stages of the disease by eradication therapy. The majority of cases with MALT lymphoma are cured by eradication therapy, but there are cases that need to be treated with rituximab alone or in combination with other drugs.
Can MALT lymphoma spread to the brain?
The clinical course of MALT lymphoma is relatively indolent and, in the majority of cases (50%), the lymphoma arises within the stomach. Primary central nervous system lymphoma (PCNSL), an uncommon variant of extranodal NHL, can affect any part of the neuraxis, including the eyes, brain, leptomeninges, or spinal cord.
What is the main function of MALT?
Mucosa-associated lymphoid tissue (MALT) is scattered along mucosal linings in the human body [1, 2, 3] and constitutes the most extensive component of human lymphoid tissue. These surfaces protect the body from an enormous quantity and variety of antigens.
What is an example of MALT?
These lymphoid tissues collectively are thus referred to as mucosa associated lymphoid tissues (MALT). Examples include tonsils, the Peyer patches within the small intestine, and the vermiform appendix.
What does MALT stand for?
Monetary Allowance in Lieu of Transportation (MALT)
Can MALT lymphoma spread to lungs?
Results: Five patients had MALT lymphoma restricted to the lung, while the remaining six had additional extrapulmonary sites detected during staging. The median time of observation without therapy was 28.1 months (inter-quartile range: 5 to 60 months); within this time, all 11 patients showed at least stable disease.
How fast does MALT lymphoma grow?
MALT lymphoma is usually slow growing (indolent) but sometimes it can be fast growing (aggressive). It usually takes a long time for it to spread outside the area where it started, and it is often diagnosed when it is stage 1 or 2.
What is the role of MALT?
What is the primary role of the MALT?
Abstract. The mucosa-associated lymphoid tissue (MALT) initiates immune responses to specific antigens encountered along all mucosal surfaces. MALT inductive sites are secondary immune tissues where antigen sampling occurs and immune responses are initiated.
Does MALT lymphoma show in blood tests?
For MALT lymphomas of the stomach, this usually involves an endoscopy. Doctors will also test for the presence of the H. pylori bacteria in the stomach. This can be done via a blood test, stool test, or breath test.
Can you be cured of MALT lymphoma?
What is the best treatment for MALT lymphoma?
The majority of cases with MALT lymphoma are cured by eradication therapy, but there are cases that need to be treated with rituximab alone or in combination with other drugs.