What is polyethylene glycol 400 made from?
Polyethylene glycol 400 (PEG400) is a clear, colorless liquid used in many industries and applications. Typically derived from petroleum, Acme-Hardesty offers a sustainable alternative manufactured from the byproducts of sugar cane processing.
What is the use of PEG 400?
Purpose: : Polyethylene glycol (PEG)-400 is a clear, colorless, viscous liquid that readily dissolves many hydrophobic drugs. It is a widely used commercial solvent and vehicle for many pharmaceutical and cosmetic products and safe for human oral consumption and topical application.
Is PEG 400 a solvent?
Within the pharmaceutical industry, PEG 400 is used as a solvent, plasticizer, and a surfactant to lower the surface tension of water. It is also used as an ointment and suppository base, along with being a lubricant for tablets and capsules making them easier for patients to swallow.
Is PEG 400 soluble in water?
Kollisolv® PEG 400 is a colorless and tasteless liquid at room temperature. It is readily soluble in water, ethanol, acetone, glycols and chloroform and insoluble in ether, paraffin, oils and fats.
Is PEG 400 the same as polyethylene glycol?
PEG 400 (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.
What are the dangers of polyethylene glycol?
Polyethylene glycol (Miralax, Glycolax) is an over-the-counter medication that treats constipation. Potential side effects of polyethylene glycol include nausea, stomach discomfort, and gas. Serious side effects are rare. They include allergic reactions, diarrhea, and serious gastrointestinal problems.
Is PEG 400 toxic?
Toxicity Profile for Polyethylene glycol 400 (1990)
Sensitization and intolerance reactions have occasionally been reported in humans exposed to PEG 400 in topical medicaments. It was of very low acute oral toxicity in a range of animal species, causing damage to the digestive tract and diarrhoea at high dose levels.
Why is PEG used in tablets?
Polyethylene glycol, referred to as PEG, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointment and suppository base, and tablet and capsule lubricant. PEG has low toxicity with absorption into the body less than 0.5%.
Is PEG 400 a surfactant?
Polyethylene glycol 400 (PEG 400), the co-surfactant used in our study, is the most commonly used polymer in drug formulations. One application of PEG 400 is as a probe to monitor the permeability of the BBB to a given substance.
Is PEG 400 an emulsifier?
RHODASURF® PEG-400 is used as emulsifier, lubricant, solvent, plasticizer, binder and wetting agent for paper, paint, textile, plastic, metal treatment, cosmetic and pharmaceutical industries.
Is PEG 400 safe to ingest?
Ingestion: Very low toxicity if swallowed. Harmful effects not anticipated from swallowing small amounts.
Is polyethylene glycol 400 toxic?
Polyethylene glycol 400 (PEG 400) is a low-molecular-weight grade of polyethylene glycol with a low-level toxicity.
What are the long term side effects of polyethylene glycol?
In our study, long-term PEG therapy did not have any major clinical adverse effects. The most common clinical adverse effect was excessively loose or frequent stools that resolved with reduction of the PEG dose. Other adverse effects were minimal and acceptable.
Who should not use polyethylene glycol?
Some groups of people should avoid polyethylene glycol, like people with a blocked intestine, appendicitis, or inflammatory bowel disease. If you need polyethylene glycol for more than 1 week, contact your healthcare provider. This could be a sign of something more serious.
Is propylene glycol cancerous?
The Department of Health and Human Services (DHHS), the International Agency for Research on Cancer (IARC), and the EPA have not classified propylene glycol for carcinogenicity. Animal studies have not shown this chemical to be carcinogen.
What is the difference between propylene glycol and polyethylene glycol?
The key difference between polyethylene glycol and propylene glycol is that polyethylene glycol is a polymer, whereas propylene glycol is a single molecular compound that can be named a diol. Polyethylene glycol and propylene glycol are important organic compounds.
Does PEG 400 contain water?
PEG 400 – Standard
This product is a mixture of ethylene oxide and water polycondensation.
Why is propylene glycol banned in Europe?
The US and European food authorities have declared it as generally safe for use in foods. However, it has become controversial since it is also an ingredient in antifreeze. This had led to health concerns about possible toxic effects from eating foods that contain it.
How long does propylene glycol stay in your system?
about 48 hours
Propylene glycol breaks down in the body in about 48 hours. However, studies of people and animals show that if you have repeated eye, skin, nasal, or oral exposures to propylene glycol for a short time, you may develop some irritation.
What does PEG do to your body?
Polyethylene glycol 3350 is used to treat occasional constipation. Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. It works by causing water to be retained with the stool. This increases the number of bowel movements and softens the stool so it is easier to pass.
Can polyethylene glycol cause neurological problems?
While it’s well-known among the medical community that PEG can trigger an allergy, cause digestive upset, or lead to electrolyte imbalances, there have been more and more reports of neurological symptoms associated with polyethylene glycol.
What are the dangers of propylene glycol?
► Propylene Glycol can cause nausea and vomiting. ► Exposure can cause headache, dizziness, lightheadedness, and passing out.
What is PEG 400 propylene glycol?
This medication is used to relieve dry, irritated eyes. Common causes for dry eyes include wind, sun, heating/air conditioning, computer use/reading, and certain medications.
What is another name for polyethylene glycol?
polyethylene oxide
Polyethylene glycol (PEG; ) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
Is PEG 400 an oil?
It is an oil-soluble liquid emulsifier (HLB 9.7), lubricant, emollient and spreading agent for personal care products.