What is the mechanism of action for triamcinolone acetonide?
It derives from a hydride of a pregnane. Triamcinolone acetonide is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist.
Is triamcinolone water soluble?
Triamcinolone acetonide, USP, is a white crystalline powder, with a molecular weight of 434.51. It, is practically insoluble in water, and sparingly soluble in dehydrated alcohol, in chloroform and in methanol. It has a melting point temperature range between 292° and 294°C.
Is triamcinolone a prodrug?
Abstract. Purpose: Triamcinolone acetonide palmitate (TAP) is a lipophilic prodrug of triamcinolone acetonide (TAA) to improve the insoluble TAA physicochemical properties for the preparation of emulsions.
How does triamcinolone reduce inflammation?
Triamcinolone is in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching.
What does triamcinolone acetonide used for?
Triamcinolone topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid). This medicine is available only with your doctor’s prescription.
What is the difference between Hydrocortisone cream and triamcinolone?
Anusol Hc (Hydrocortisone) is a good topical steroid to try for treating minor rashes or skin irritation. Treats inflamed and itchy skin as well as mouth lesions. Kenalog (triamcinolone) effectively treats certain skin inflammation disorders, but should only use for a maximum of 2 weeks at a time.
What is the half life of triamcinolone?
During the period of logarithmic fall in plasma triamcinolone concentration (22 to 480 minutes after injection), the half-life of triamcinolone was 116.7 ± 7.4 minutes; the half-life of hydrocortisone measured by the same procedure was 54.3 ± 3.6 minutes.
What is triamcinolone acetonide made of?
Each gram of Triamcinolone Acetonide (triamcinolone acetonide cream) Cream USP, 0.1% contains 1 mg Triamcinolone Acetonide (triamcinolone acetonide cream) in a cream base consisting of cetyl alcohol, glyceryl monostearate, cetyl esters wax, isopropyl palmitate, polysorbate-60, polysorbate-80, propylene glycol and …
Is triamcinolone fast acting?
Triamcinolone is a long-acting steroid that does not have pharmacokinetic studies in humans in its intramuscular formulation.
What happens if you use triamcinolone for too long?
Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time.
Why is triamcinolone banned?
Triamcinolone acetonide (TA) is classified as an S9 glucocorticoid in the 2014 Prohibited List published by the World Anti-Doping Agency, which caused it to be prohibited in-competition when administered orally, intravenously, intramuscularly or rectally.
When should you not use triamcinolone acetonide?
Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water. If you or your child are using the spray form on or near the face, protect your nose to avoid breathing it in and make sure that your eyes are covered.
How long does triamcinolone stay in your system?
Results: The terminal elimination half-life of triamcinolone in a noncompartmental analysis was 213 hours. The peak median triamcinolone concentration of 3.6 ng/mL was detected within 24 hours after the injections. Serum cortisol levels were < 30 ng/mL for an average of 4.4 days.
What is the half-life of triamcinolone?