Which test characteristic can be used to distinguish between Corynebacterium ulcerans and Corynebacterium pseudotuberculosis?
ulcerans and C. pseudotuberculosis) are pyrazinamidase negative while other corynebacteria are positive. The urease test is used to determine the ability of an organism to split urea, through the production of the enzyme urease.
How is Corynebacterium diagnosed?
Diagnosis. Clinical diagnosis depends upon culture-proven toxigenic C diphtheriae infection of the skin, nose, or throat combined with clinical signs of nasopharyngeal diphtheria (e.g., sore throat, dysphagia, bloody nasal discharge, pseudomembrane).
What Agar does Corynebacterium grow on?
Tinsdale agar (TIN) is used for the primary isolation and identification of Corynebacterium diphtheriae. The medium differentiates between C. diphtheriae and diphtheroids found in the upper respiratory tract.
How serious is Corynebacterium?
Diphtheria is a serious infection caused by strains of bacteria called Corynebacterium diphtheriae that make toxin. It can lead to difficulty breathing, heart rhythm problems, and even death. CDC recommends vaccines for infants, children, teens, and adults to prevent diphtheria.
Can Corynebacterium be catalase negative?
All species are catalase positive.
All species are oxidase negative except for Corynebacterium bovis, Corynebacterium aurimucosum, Corynebacterium doosanense, and Corynebacterium maris (below).
What antibiotics cover Corynebacterium?
Many antibiotics are effective, including penicillin, erythromycin, clindamycin, rifampin, and tetracycline; erythromycin or penicillin is the treatment of choice and is usually given for 14 days.
How do you treat Corynebacterium?
Where is Corynebacterium found in the body?
They are ubiquitous and can be found on the skin and in the upper respiratory and gastrointestinal tracts. The primary pathogen in this group is Corynebacterium diphtheriae, the etiologic agent of diphtheria. Additional corynebacteria include 45 species, 30 of which on rare occasion cause human disease.
Does Corynebacterium grow on MacConkey Agar?
The presence of coryneform organisms in smears is diagnostic. Culture on blood agar, selective blood agar and MacConkey agar are also diagnostic, they do not grow on MacConkey.
Is Corynebacterium aerobic or anaerobic?
aerobic
Corynebacteria (from the Greek words koryne, meaning club, and bacterion, meaning little rod) are gram-positive, catalase-positive, aerobic or facultatively anaerobic, generally nonmotile rods.
What antibiotic kills Corynebacterium?
The goal is both to kill the organism and to terminate toxin production. Many antibiotics are effective, including penicillin, erythromycin, clindamycin, rifampin, and tetracycline; erythromycin or penicillin is the treatment of choice and is usually given for 14 days.
Does Corynebacterium require isolation?
Follow-up cultures should be done at 48 hours after treatment and again at 2 weeks to document clearance. Isolation should continue until two consecutive cultures 24 hours apart are negative.
Are all Corynebacterium catalase positive?
Does doxycycline treat Corynebacterium?
The susceptibilities of 265 strains of Corynebacterium species and other non-spore-forming gram-positive bacilli to 18 antimicrobial agents were tested. Most strains were susceptible to vancomycin, doxycycline, and fusidic acid.
Can Corynebacterium cause sepsis?
C. jeikeium was initially described in 1976 as a highly resistant coryneform bacteria that caused severe sepsis in patients with hematologic malignancies and profound neutropenia and in one patient with a ventricular CSF shunt.
What antibiotic is used to treat Corynebacterium?
Which antibiotic is mostly used to treat Corynebacterium infection?
Doxycycline, rifampicin, and antibiotics belonging to the glycopeptides class (vancomycin and teicoplanin) are the most active drugs against this microorganism.
How do I get rid of Corynebacterium?
Antibiotics are the treatment of choice for nondiphtherial corynebacteria infections. Many species and groups are sensitive to various antibiotics, including penicillins, macrolide antibiotics, rifampin, and fluoroquinolones. However, antibiotic susceptibility can vary, and susceptibility testing is recommended.
Is Corynebacterium contagious?
Diphtheria is a highly contagious and potentially life-threatening bacterial disease caused by Corynebacterium diphtheriae. There are two types of diphtheria: respiratory and cutaneous.
Is Corynebacterium oxidase positive or negative?
All species are oxidase negative except for Corynebacterium bovis, Corynebacterium aurimucosum, Corynebacterium doosanense, and Corynebacterium maris (below). Many species are facultatively anaerobic and some are aerobic. Chemoorganotrophs.
Can Corynebacterium be a contaminant?
Corynebacterium is a genus that can contaminate blood cultures and also cause severe infections like infective endocarditis (IE).
How is Corynebacterium transmitted?
It is transmitted from person to person through close physical and respiratory contact.
What part of the human body does Corynebacterium colonize?
After gaining access to the host, the bacteria usually colonize in the upper respiratory tract. They typically do not invade tissue to cause disseminated bacteremia.
Is Corynebacterium an STD?
Corynebacterium vaginale is a sexually transmitted organism which was first recognized in 1953. It appears to utilize glycogen stored in vaginal epithelial cells, causing a malodorous vaginal discharge characterized by an abnormally high pH (5.0 to 5.5) and composed mainly of epithelial cells and hordes of bacilli.