Why does reperfusion hurt?
Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).
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| Reperfusion injury | |
|---|---|
| Other names | Reperfusion insult |
| Specialty | Cardiology |
What happens during reperfusion injury?
Reperfusion injury is a term that refers to the damage that occurs after blood supply is restored to a tissue or organ after a period of ischemia.
What are the three components of reperfusion injury?
Components of reperfusion injury including myocardial edema, hemorrhage, calcium deposition and microvascular obstruction (MO) have been demonstrated using MR and CT technologies.
What are examples of reperfusion injury?
Table 1
| Affected organ | Example of clinical manifestation |
|---|---|
| Circulatory arrest | Hypoxic brain injury; multiple organ failure; acute kidney injury |
| Sickle cell disease | Acute chest syndrome; pulmonary hypertension, priapism, acute kidney injury |
| Sleep apnea | Hypertension; diabetes |
| Ischemia and reperfusion during major surgery |
How long does reperfusion pain last?
In my experience the syndrome occurs in less than 10% of patients and is self-limited, often resolving 1 week after revascularization. In the calf, severe reperfusion injury may result in compartment syndrome.
What are signs of reperfusion?
Early signs of reperfusion were ST-segment normalization (likelihood ratio 16.0), development of terminal T-wave inversion (likelihood ratio 10.6), accelerated idioventricular rhythm (likelihood ratio 6.0), and a twofold increase in ventricular premature complexes (likelihood ratio 2.5).
How do you overcome reperfusion injury?
Ischemia reperfusion injury has been treated using several therapeutic gases, including hydrogen (H2), hydrogen sulfide (H2S), NO, and carbon monoxide (CO). 50 , 51 Carbon monoxide, one of the byproducts of the heme oxygenase system, can provide cytoprotection by modulating intracellular signaling pathways through its …