How dendrimers are used in nano material synthesis?
Dendrimers can be synthesized by two major approaches. In the divergent approach, used in early periods, the synthesis starts from the core of the dendrimer to which the arms are attached by adding building blocks in an exhaustive and step-wise manner.
What are dendrimers used for?
Due to their size, dendrimers are used in nanomedicine research. They are found to be useful as delivery or carrier systems for drugs and genes, but studies have shown that some dendrimers have medicinal uses of their own, mostly due to their antifungal, antibacterial and cytotoxic properties [5,6].
How do dendrimer conjugated nanoparticles target cancer cells specifically?
The multivalency and hydrophobic inner core of dendrimers can then be utilized to deliver toxic molecules through covalent conjugation and encapsulation, respectively, to kill cancer cells precisely with guidance of the conjugated mAbs.
What do you mean by dendrimers?
Dendrimers are highly defined artificial macromolecules, which are characterized by a combination of a high number of functional groups and a compact molecular structure. A rapid increase of importance in the chemistry of dendrimers has been observed since the first dendrimers were prepared.
What are the types of dendrimers?
2. Types of dendrimers
| Dendrimer types | Application | Drug |
|---|---|---|
| Peptide dendrimer | Gene therapy | DNA |
| Dendronized polypeptide (denpol) dendrimer | siRNA delivery | siRNA |
| Glycodendrimers | Anti-HIV dendritic cell-based immunotherapy | – |
| Polypolypropylene oxide cored PAMAM | Solubility enhancement | Ketoprofen, diflunisal, ibuprofen |
How are dendrimers used in drug delivery?
Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach.
Which nanoparticles are used in cancer treatment?
mAb Nanoparticles
Monoclonal antibodies are widely used in cancer treatment for their particular targeting abilities [65]. These mAb are now combined with NPs to form antibody–drug conjugates (ADCs). These are proved to be highly specific and compelling than cytotoxic drugs or mAb alone.
How do nanoparticles target cancer cells?
The drug molecules carried by nanoparticle are released in the extracellular matrix and diffuse throughout the tumor tissue. The particles carry surface ligands to facilitate active targeting of particles to receptors present on target cell or tissue.
What are dendrimers Slideshare?
Dendrimer Polymers techniques is a controlled release system which helps to s… IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research…
What are some desirable features of dendrimers for drug delivery?
[23] Unlike traditional polymers, dendrimers have received considerable attention in biological applications due to their high water solubility,[24] biocompatibility,[25] polyvalency[12] and precise molecular weight. [26] These features make them an ideal carrier for drug delivery and targeting applications.
How is nanotechnology used in cancer?
Nanotechnology can provide rapid and sensitive detection of cancer-related molecules, enabling scientists to detect molecular changes even when they occur only in a small percentage of cells. Nanotechnology also has the potential to generate entirely novel and highly effective therapeutic agents.
How can nanotechnology help cure cancer?
The traditional use of nanotechnology in cancer therapeutics has been to improve the pharmacokinetics and reduce the systemic toxicities of chemotherapies through the selective targeting and delivery of these anticancer drugs to tumor tissues.
What nanoparticles are used in cancer?
What is nanotechnology for cancer treatment?
Nanotechnology offers the means to target chemotherapies directly and selectively to cancerous cells and neoplasms, guide in surgical resection of tumors, and enhance the therapeutic efficacy of radiation-based and other current treatment modalities.
Which is the example of dendrimer?
Examples of several types of dendrimers include those which have immense applications in drug delivery including poly(amidoamine) (PAMAM) dendrimers, poly(propylene imine) (PPI) dendrimers, polyether-copolyester (PEPE) dendrimers, PEGylated dendrimers, peptide dendrimers, etc.
What are the different ways of drug loading in dendrimers?
The dendrimer architecture has three main sites for drug entrapment by using various mechanisms: (i) void spaces (by molecular entrapment); (ii) branching points (by hydrogen bonding); and (iii) outside surface groups by (charge–charge interactions) (Figure 1).
Why are dendrimers used in drug delivery?
Oral Bioavailability: Entrapment of drugs in dendrimers helps to enhance solubility, stability and dissolution. These properties eventually help to enhance oral bioavailability of the drug.
Can cancer be cured by nanotechnology?
Doctors have used nanotechnology to treat cancer for more than a decade. Two approved treatments — Abraxane and Doxil — help chemotherapy drugs work better. Abraxane is a nanoparticle made from the protein albumin attached to the chemo drug docetaxel. It stops cancer cells from dividing.
What nanomaterials are used in cancer treatment?
Over the past decades, a variety of nanoscale drug delivery systems have been extensively explored to deliver anti-cancer agents specifically to cancers. These nanosystems include polymeric micelles, polyelectrolyte complex micelles, liposomes, dendrimers, nanoemulsions, and nanoparticles.
Why are nanoparticles used in cancer?
Nanoparticles (1–100 nm) can be used to treat cancer due to their specific advantages such as biocompatibility, reduced toxicity, more excellent stability, enhanced permeability and retention effect, and precise targeting. Nanoparticles are classified into several main categories.
How do nanoparticles detect cancer?
Detection through cell surface protein recognition
The main method to detect cancer cells relies on binding of nanoparticle probes conjugated with moieties (protein, short peptides, antibodies, oligonucleotide aptamers) to surface markers on cancer cells and on those entering cells and detecting genetic content.
What is nanotechnology in cancer treatment?
How do nanoparticles work in cancer treatment?
Specially designed nanoparticles deliver medicines like chemotherapy straight to the tumor. They don’t release the medicine until they reach it. This stops the drugs from damaging healthy tissues around the tumor. That damage is what causes side effects.
When was nanotechnology used in cancer treatment?
As far back as 1995, nanotechnology has offered clinicians novel tools to treat patients. Find a list of the currently approved nano-enabled therapeutics here.