How does lipoprotein A affect the heart?
The lipoprotein (a) structure, which includes an LDL-like part. High levels of lipoprotein (a) increase your likelihood of having a heart attack, a stroke, and aortic stenosis, especially if you have familial hypercholesterolemia or signs of coronary heart disease.
What should I do if I have high lipoprotein A?
Treatment of elevated Lipoprotein (a) is based on a person’s risk of heart attack or stroke. A healthy diet and lifestyle are the first step to reducing heart attack and stroke risk from elevated Lipoprotein (a). Medications also may help. ‘ Statins’ do not lower Lipoprotein (a) levels.
What type of lipoprotein is associated with a lower risk of heart disease?
HDL (high-density lipoprotein), or “good” cholesterol, absorbs cholesterol and carries it back to the liver. The liver then flushes it from the body. High levels of HDL cholesterol can lower your risk for heart disease and stroke.
What are the symptoms of high lipoprotein A?
A high level of LP(a) in the blood has now been identified as a risk factor for diseases of the heart and blood vessels – known as cardiovascular disease or CVD. It can cause atherosclerosis (furring up of arteries), heart attacks, strokes, aortic valve disease and heart failure.
Can aspirin lower lipoprotein A?
Results: Aspirin lowered serum Lp(a) concentrations to approximately 80% of the baseline values in patients with high Lp(a) concentrations (>300 mg/L). The percentage of decrease in serum Lp(a) was larger in patients with high Lp(a) than in patients with low Lp(a) (<300 mg/L), irrespective of apo(a) isoform size.
Do statins reduce lipoprotein A?
Long term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia.
How much lipoprotein A is considered high?
There is evidence that the risk of heart disease may start to rise at 30 mg/dl (about 75 nmol/L), and it rises more steeply at levels of 50 mg/dL (about 125 nmol/L) and higher. An estimated one in seven people are at or above this threshold.
Is high lipoprotein A genetic?
Elevated Lipoprotein(a) [Lp(a)], also called hyperlipoproteinemia(a), is a highly prevalent genetic risk factor for cardiovascular disease (CVD).
How common is elevated lipoprotein A?
Indeed, elevated Lp(a) is the most common genetic dyslipidemia, with nearly 1 in 5 individuals affected in the United States [ie, based on Lp(a) >50 mg/dL or >120 nmol/L].
What medication reduces lipoprotein A?
Niacin reduces lipoprotein (a) by 15% to 25%, but does not reduce death or ischemic cardiovascular events [42,43]. Anacetrapib, a CETP inhibitor which is no longer available, lowers Lp(a) by 25% with only modest cardiovascular benefits, which are likely explained by other effects on the lipid profile [44].
How can I lower my lipoprotein A levels naturally?
Other natural products, such as pectin, Ginkgo biloba, flaxseed, red wine, resveratrol and curcuminoids can also reduce elevated Lp(a) concentrations but to a lesser degree. In conclusion, aforementioned natural products may represent promising therapeutic agents for Lp(a) lowering.
Can you live long with high lipoprotein?
This analysis suggests that the mortality risk for individuals with Lp(a) levels equal to or above the 95th percentile is equivalent to being 1.5 years older in chronologic age.
Is it possible to lower lipoprotein A?
Although healthy eating and exercise can help reduce LDL cholesterol, there’s no evidence that a healthier lifestyle can lower Lp(a). Your Lp(a) level is currently thought to be dictated almost entirely by the genes you inherit.
Can exercise lower lipoprotein A?
In addition to its known beneficial effects on the classic cardiovascular risk factors, regular physical exercise may reduce the risk of cardiovascular disease in diabetic patients by reducing Lp(a) levels in those with elevated Lp(a) and producing favorable qualitative LDL modifications.
How common is high lipoprotein A?
What causes lipoprotein A to be high?
Elevated blood Lp(a) levels are primarily due to genetic variations in the LPA gene that encodes for apo(a) and cannot be lowered by diet, exercise or current lipid-lowering therapies.