How is exogenous antigen processed?
The exogenous pathway is utilized by specialized antigen-presenting cells to present peptides derived from proteins that the cell has endocytosed. The peptides are presented on MHC class II molecules. Proteins are endocytosed and degraded by acid-dependent proteases in endosomes; this process takes about an hour.
Is an inhibitor of endocytic processing?
Emetine is a protein synthesis inhibitor and Chloroquine inhibits the endocytosis pathway.
What is endogenous antigen processing?
Synonyms: antigen presentation, endogenous antigen. Definition: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.
Which is an inhibitor of the endocytic processing Mcq?
What is the difference between processing of endogenous antigens and processing exogenous antigens?
The main difference between exogenous and endogenous antigens is that the exogenous antigens enter the body from the outside whereas the endogenous antigens are generated inside the body. Exogenous and endogenous antigens are the two main types of antigens in the body. They are classified based on the origin.
How is the MHC I system different from the MHC II system?
MHC I glycoproteins are present in all nucleated cells. MHC II glycoproteins are only present on specialised antigen-presenting cells (APCs), including macrophages that engulf foreign particles such as bacteria, dendritic cells that present antigen to T cells, and B cells that produce antibodies.
What is the main difference between the action of MHC class 1 and MHC Class 2?
The main difference between MHC class 1 and 2 is that MHC class 1 molecules present antigens to cytotoxic T cells with CD8+ receptors whereas MHC class 2 molecules present antigens to helper T cells with CD4+ receptors.
What is the endocytic pathway?
The endocytic pathway of mammalian cells consists of distinct membrane compartments, which internalize molecules from the plasma membrane and recycle them back to the surface (as in early endosomes and recycling endosomes), or sort them to degradation (as in late endosomes and lysosomes). The principal components of the endocytic pathway are:
What is the endocytic pathway of antigen processing and presentation?
Endocytic pathway of antigen processing and presentation: 1 The endocytic pathway processed and present the exogenous Ag. 2 At first APC phagocytosed, endocytosed or both, the antigen. 3 Macrophage and dendritic cells internalize the antigen by both the process. 4 While other APCs are non-phagocytic or poorly phagocytic.
What happens to internalized molecules in the endocytic pathway?
In the endocytic pathway, internalized molecules are delivered to early endosomes, where efficient sorting occurs. Although some molecules, in particular recycling receptors, are rapidly recycled back to the plasma membrane for reutilization; others, including downregulated receptors, are transported to late endosomes and lysosomes for degradation.
What is the endocytosis pathway of a coated pit?
Endocytosis pathways. Coated pits can concentrate large extracellular molecules that have different receptors responsible for the receptor-mediated endocytosis of ligands, e.g. low density lipoprotein, transferrin, growth factors, antibodies and many others.