What is OAT1 3?
OAT1 and 3 are multispecific exchangers or antiporters that transport predominantly anionic substrates against a concentration gradient from the blood into proximal tubule cells for subsequent elimination into the urine.
How many transmembrane domains does OAT1?
OAT1 is believed to have twelve transmembrane domains.
What are oat3 inhibitors?
Drugs which inhibit organic anion transporter 3. An isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation.
What does the organic anion transporter do?
Organic anion transporters (OATs) are the secondary/tertiary active transporter proteins that regulate anion balance in the body. They are primarily expressed in the kidney and liver and control the excretion of common drugs, toxins, and endogenous metabolites into the urine.
What is OCT1 substrate?
A large number of drugs have been identified as substrates or inhibitors of OCT1. A key drug substrate of OCT1 is the oral antidiabetic drug metformin, which must be transported into the hepatocyte (and adipose cells) to exert its pharmacological effect.
What is MATE1 transporter?
MATE1 is a multidrug and toxin extrusion transporter encoded by the SLC47A1 gene. MATE1 is expressed in the apical membrane in the kidney and liver and can mediate elimination of substrates. BioIVT offers MATE1 substrate and inhibition assays for transport in polarized mammalian cells.
What is MRP transporter?
MRPs are organic anion transporters; i.e., they transport anionic drugs, exemplified by methotrexate, and neutral drugs conjugated to acidic ligands, such as glutathione (GSH), glucuronate, or sulfate.
What is oat3 substrate?
Which is competitive inhibitor of organic anionic transporter?
Competitive inhibition of human organic anion transporters 1 (SLC22A6), 3 (SLC22A8) and 4 (SLC22A11) by major components of the medicinal herb Salvia miltiorrhiza (Danshen) Drug Metab Pharmacokinet.
What is an example of an organic anion?
. Examples of such anions are hippurate, long chain fatty acids, bile salts, urate, prostaglandins, antibiotics, and diuretics, and examples of cations are choline, catecholamines, histamine, quinine, and cimetidine.
Which is the competitive inhibitor of organic anionic transporter?
What is organic cation transporter 1?
Organic cation transporters (OCTs) belong to the solute carrier family 22 of polyspecific transporter proteins that are expressed in the liver, kidney, intestine, and other organs, transporting organic cationic compounds such as nutrients, endogenous amines, and many cationic drugs.
What is Mate1 substrate?
Substrates for MATE1 and MATE2-K are typical organic cations, TEA, 1-methyl-4-phenylpyridinium (MPP), metformin, cimetidine, procainamide and so on (Table 2) (Tanihara et al., 2007).
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Where is MRP2 found?
MRP2 is located at the apical plasma membrane of the enterocytes where it is involved in exporting various substrates from the intestinal epithelium into the intestinal lumen.
What is the full name of BCRP?
BCRP was first identified in breast cancer cells. Also called breast cancer resistance protein.
What is an inorganic anion?
Inorganic anions refer to the combination of: Common anions: chloride, fluoride, bromide, nitrate, nitrite, sulfate, and phosphate. Inorganic disinfection byproducts (DBPs): chlorate, chlorite, and bromate. Other anions, such as perchlorate and chromate.
How many clones of human organic anion transporting polypeptide are identified?
So far, 40 members of the OATP/SLCO superfamily have been identified in humans, rats and mice. Most OATPs are expressed in multiple tissues including the blood-brain barrier (BBB), choroid plexus, lung, heart, intestine, kidneys, placenta and testes.
Where are organic cation transporters located?
the liver
Organic cation transporters (OCTs) belong to the solute carrier family 22 of polyspecific transporter proteins that are expressed in the liver, kidney, intestine, and other organs, transporting organic cationic compounds such as nutrients, endogenous amines, and many cationic drugs.
How do organic cation transporters work?
9.6 Organic Cation Transporters (OCTs) OCT refers to one of the most abundant transporters of the liver. OCTs are considered as poly-specific membrane transporters that act by mediating the hepatic uptake of hydrophilic compounds that are small and positively charged including dopamine, serotonin, and histamine.
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What is MRP2 gene?
The ABCC2 gene provides instructions for producing a protein called multidrug resistance protein 2 (MRP2). This protein is one of a family of multidrug resistance proteins involved in the transport of substances out of cells.
What is the difference between MRP I and MRP II?
The difference being, MRP II uses additional data from accounting records and sales for further analysis and forecasting of manufacturing requirements. MRP I stands for material requirements planning, while MRP II stands for manufacturing resource planning.