What is SSA Ro60?
SSA-52 (Ro52) and/or SSA-60 (Ro60) antibodies are associated with a diagnosis of Sjögren syndrome, systemic lupus erythematosus (SLE), and systemic sclerosis. SSA-52 antibody overlaps significantly with the major SSc-related antibodies.
What is the normal range for SSA antibody?
Table 1
| Case 1 | Normal range | |
|---|---|---|
| Anti-SSA/Ro52・Ro60 antibodies (anti-SSA/Ro antibodies) | 203 | < 10 U/mL |
| Anti-SSB/La antibodies | < 1.0 | < 10 U/mL |
| Anti-Scl-70 antibodies | 10.7 | < 10 U/mL |
| Rheumatoid factor (RF) | 16 | < 15 U/mL |
What are SSA and SSB antibodies?
INTRODUCTION. Anti‐SSA and ‐SSB antibodies are clinically important antinuclear antibody (ANA) in patients with systemic rheumatic diseases. These antibodies are found in Sjögren’s syndrome (SS), as well as other systemic autoimmune diseases (ADs), such as systemic lupus erythematosus (SLE), myositis, scleroderma, etc.
What is the difference between Sjogren’s A and B?
SS-A antibodies are found in approximately 60-80% of Sjögren’s syndrome patients. SS-B antibodies are less common, being found in approximately 30-50% of Sjögren’s syndrome patients. SS-A antibodies thus occur commonly by themselves. However, it is very uncommon for SS-B antibodies to occur alone.
What is a high Sjogren’s anti-SSA?
Elevated Sjögren’s antibodies—anti-SS-A and anti-SS-B—are suggestive of inflammatory connective tissue disease. Elevated results on this test may indicate Sjögren’s syndrome or another autoimmune disease such as lupus or rheumatoid arthritis.
What is SS-A antibody?
Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS).
What is the relationship between Ro60 and SSA antibodies?
The epitope of the Ro60 protein is similar to that of the Epstein-Barr virus, and the presence of the virus may enhance the autoimmune response to Ro60, as anti-Epstein Barr antibodies can target the protein. Anti-Ro/SSA antibodies are found in 40-90% of patients with systematic lupus erythematosus (SLE).
What is the difference between SSA/ssa/ro60 and anti-ro52/trim21?
Thus, the presence anti-SSA/Ro60 is related to autoimmune processes, mainly systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS), whereas anti-Ro52/TRIM21 shows a wider spectrum of disease associations [1–7].
Is Ro60 part of the TRIM family?
Ro60 is not part of the TRIM family. Ro60 is encoded by a gene 32 kb in length and acts to regulate the fate of misfolded RNA within the host cell. Ro60 forms a ribonucleoprotein complex with one molecule of noncoding Y1, Y3, Y4, or Y5RNA, all of which are approximately 100 nucleotides in length, to form the epitope that Anti-Ro60 recognizes.
What does ssa-52 (Ro52) stand for?
SSA-52 (Ro52) and/or SSA-60 (Ro60) antibodies are associated with a diagnosis of Sjögren syndrome, systemic lupus erythematosus (SLE), and systemic sclerosis. SSA-52 antibody overlaps significantly with the major SSc-related antibodies. SSA-52 (Ro52) antibody occurs frequently in patients…