What is the function of Bcl-2 proteins?
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers of cell death. Together they regulate and mediate the process by which mitochondria contribute to cell death known as the intrinsic apoptosis pathway.
What type of protein is Bcl-2?
regulator proteins
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any organism. Chr.
Is BCL2 anti-apoptotic?
Anti-apoptotic proteins (eg, BCL-2, BCL-XL, MCL-1, BFL-1, BCL-W, and BCL2L10) possess BH 1–4 domains and they preserve outer mitochondrial membrane integrity by inhibiting the pro-apoptotic members (Table 1).
What is the role of Bcl-2 proteins in normal cell physiology?
However, before apoptosis is induced, BCL-2 proteins have critical roles in normal cell physiology related to neuronal activity, autophagy, calcium handling, mitochondrial dynamics and energetics, and other processes of normal healthy cells.
How do Bcl-2 family proteins interact with dynamin-like GTPases?
Many studies now suggest close interactions between BCL-2 family proteins and the dynamin-like GTPases Drp1 and Mfn1/2 that physically mediate mitochondrial outer membrane fission and fusion, respectively (Li et al. 2008; Rolland et al. 2009). Here too, BCL-2 family proteins also appear to have polar opposite effects, but with a twist.
Are Bcl-2 proteins polar or nonpolar?
Here too, BCL-2 family proteins also appear to have polar opposite effects, but with a twist.
What is the role of Bcl-2 in the pathophysiology of endoplasmic reticulum infection?
Dremina ES, Sharov VS, Kumar K, Zaidi A, Michaelis EK, Schoneich C 2004. Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA).