Does p53 interact with beta-catenin?
Recent studies have demonstrated that increased p53 levels can downregulate the level of β-catenin and its signaling activity, without a direct interaction between p53 and β-catenin (Liu et al., 2001; Matsuzawa and Reed, 2001; Sadot et al., 2001), indicating that this process may involve p53 target genes.
Does Ras interact with beta-catenin?
β-Catenin directly interacts with RAS, thereby preventing GSK3β-dependent phosphorylation and degradation, defining the basis for the synergistic effect of β-catenin and RAS on cancer growth. β-Catenin directly interacts with RAS at the α-interface that contains GSK3β phosphorylation sites.
What is beta catenin signaling?
Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal.
What is the function of beta catenin?
The protein beta-catenin is an essential component of intercellular junctions and the Wnt growth factor signaling pathway. In many cancers, mutation of Wnt pathway components leads to activation of oncogenes by the beta-catenin-Tcf transcription factor complex.
Is β-catenin a druggable target for drug development?
However, recent discoveries of small molecules that directly bind to β-catenin suggest that β-catenin is a potentially druggable target that is yet to be drugged.
What is the Wnt β catenin pathway?
The Wnt/β-catenin pathway is associated with the regulation of cell proliferation and differentiation [12,13], embryonic development, and maintenance of homeostasis and is linked to many human diseases [14].
Can CBP/β-catenin signaling be activated in HCV-protein-expressing livers?
These results clearly indicated that CBP/β-catenin signaling was activated in HCV-protein-expressing livers, and that inhibition of CBP/β-catenin by PRI-724 was effective at counteracting HCV-induced liver fibrosis.