What does TGF B do in the body?

What does TGF B do in the body?

Transforming growth factor β (TGF-β) is a highly pleiotropic cytokine that plays an important role in wound healing, angiogenesis, immunoregulation and cancer. The cells of the immune system produce the TGF-β1 isoform, which exerts powerful anti-inflammatory functions, and is a master regulator of the immune response.

Is TGF-beta anti-inflammatory?

These studies show that TGF-β functions as an anti-inflammatory cytokine in cell types that are also present in atherosclerotic plaques. TGF-β is also known to be an important fibrotic cytokine that plays an important role in matrix remodeling and collagen synthesis.

What does TGF b1 test for?

This is a quantitative EIA assay for the human cytokine Transforming Growth Factor beta 1 ( TGF ß-1). TGF β-1 plays a role in tissue regulation and is used as an aid to determine underlying causes of unusual or inflammatory disorders.

Where are TGF?

Jay and Romell were raised in the town of Dudley in the West Midlands; just outside of Birmingham, England. Jay being born at Wordsley hospital in West Midlands, and Romell being born in Lisbon, Portugal, before later settling down in Birmingham, where he would soon meet Jay and Luke at school.

How can TGF beta be reduced?

The main strategies for inhibition of TGF-β signaling pathway is to include compounds that interfere with the binding of TGF-β to its receptors, drugs that block intracellular signaling, and antisense oligonucleotides.

Who produces TGF beta?

TGF-beta is produced by many but not all parenchymal cell types, and is also produced or released by infiltrating cells such as lymphocytes, monocytes/macrophages, and platelets. Following wounding or inflammation, all these cells are potential sources of TGF-beta.

What causes the release of TGF-beta?

What is the specific activity of recombinant human TGF-beta 1?

The specific activity of Recombinant Human TGF-beta 1 is approximately 2.5 x 10 4 U/μg, which is calibrated against human TGF‑ beta 1 Standard (NIBSC code: 89/514). Specific activity is for reference purposes only and is not routinely tested.

How do you dilute human TGF-β1 recombinant protein?

Human TGF-β1 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile 10 mM HCl at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed.

Can recombinant human TGF beta 1 protein be reconstituted in PBS or water?

Can Recombinant Human TGF beta 1 Protein (Catalog # 240-B or 240-B/CF) be reconstituted in PBS or water? Recombinant Human TGF beta 1 Protein (Catalog # 240-B or 240-B/CF) needs to be reconstituted to 100 μg/mL in sterile 4 mM HCl containing 0.1% BSA or 4 mM HCl.

What is TGF-beta 1-2 and-3?

TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition (1‑4).

Related Post