What is a PSP in clinical trials?
RT001 in Patients With Progressive Supranuclear Palsy (PSP) PROGRESSIVE SUPRANUCLEAR PALSY
| Primary Purpose: | Treatment |
| Official Title: | A Randomized, Double-blind, Controlled, Phase 2 Study to Assess Efficacy, Long Term Safety and Tolerability of RT001 in Subjects With Progressive Supranuclear Palsy |
What does PSP mean in healthcare?
Progressive supranuclear palsy (PSP) is a rare neurological condition that can cause problems with balance, movement, vision, speech and swallowing. It’s caused by increasing numbers of brain cells becoming damaged over time.
Is PSP a serious illness?
Progressive supranuclear palsy is an uncommon brain disorder that causes serious problems with walking, balance and eye movements, and later with swallowing. The disorder results from deterioration of cells in areas of your brain that control body movement, coordination, thinking and other important functions.
What are the first signs of PSP?
Early symptoms
- sudden loss of balance when walking that usually results in repeated falls, often backwards.
- muscle stiffness, particularly in the neck.
- extreme tiredness.
- changes in personality, such as irritability, apathy (lack of interest) and mood swings.
- changes in behaviour, such as recklessness and poor judgement.
What are the final stages of PSP?
The final stages of PSP are usually dominated by an increasingly severe dysarthria and dysphagia. These features are usually described as being part of a pseudo-bulbar palsy, as brisk jaw and facial jerks may be present.
Who has PSP?
PSP is found most frequently in people age 60 and older, but it has also been found in people as young as 40. It’s a little bit more common in men than women.
What are the 4 stages of PSP?
The four stages are:
- Early stage.
- Mid stage.
- Advanced stage.
- End of life stage.
Can PSP be fatal?
Although PSP isn’t fatal, symptoms do continue to worsen and it can’t be cured. Complications that result from worsening symptoms, such as pneumonia (from breathing in food particles while choking during eating), can be life threatening.
How long do people with PSP live?
People with PSP typically pass away from complications within six to ten years – but it depends on the person. Walking can become difficult, if not impossible, after five or six years.
How long can a person live with PSP?
How long do PSP patients live?
PSP typically progresses to death in 5 to 7 years,1 with Richardson syndrome having the fastest rate of progression.
Is PSP worse than Parkinson’s?
On average, PSP gets worse quicker than Parkinson’s and doesn’t respond as well to medications. People with Parkinson’s usually bend forward, while people with PSP stand very straight, or even slightly backwards. Problems with swallowing and with speaking appear early with PSP and they are far more severe.
How quickly does PSP progress?
How long is life expectancy with PSP?
9 21 The median life expectancy from symptom onset to death is 9 years.
Is PSP always fatal?
Most of the time, it affects people in late middle age or older. Although PSP isn’t fatal, symptoms do continue to worsen and it can’t be cured. Complications that result from worsening symptoms, such as pneumonia (from breathing in food particles while choking during eating), can be life threatening.
What is the life expectancy for someone with PSP?
These complications can be fatal. The rate of progression with PSP varies significantly from person to person. The average life expectancy after diagnosis is approximately seven years, which means that half the people with PSP will live longer, some up to 15 years, and half will live shorter, even as short as 3 years.