What is MCL-1 Gene?

What is MCL-1 Gene?

Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is frequently observed in many tumor types and is closely associated with tumorigenesis, poor prognosis and drug resistance.

Is MCL-1 an oncogene?

Mcl-1 is a potent oncogene that is regulated at the transcriptional, posttranscriptional, and posttranslational levels.

What does MCL-1 stand for?

MCL1

What does MCL1 do?

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of cytochrome c from mitochondria.

What is an MCL 1 inhibitor?

An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities.

What is MCL lead ECG?

MCL 1 or Modified V1. Another popular monitoring lead is the MCL1 lead (or modified V1). To connect this lead, the negative electrode is placed near the left shoulder, usually under the outer third of the left clavicle, and the positive electrode is placed to the right of the sternum in the fourth intercostal space.

What is MCL in biology?

Abstract. MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy.

What is an MCL-1 inhibitor?

What chromosome is MCL-1 on?

Chromosome 1
MCL1

Is survivin a protein?

Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent functions i.e. regulating cell proliferation and cell death.

What does MCL stand for heart?

MCL is an abbreviation for medial collateral ligament.

Where is the MCL chest lead placed?

Another popular monitoring lead is the MCL1 lead (or modified V1). To connect this lead, the negative electrode is placed near the left shoulder, usually under the outer third of the left clavicle, and the positive electrode is placed to the right of the sternum in the fourth intercostal space.

What myeloid means?

Listen to pronunciation. (MY-eh-loyd) Having to do with or resembling the bone marrow. May also refer to certain types of hematopoietic (blood-forming) cells found in the bone marrow.

What is the survivin gene?

Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death.

Is caspase 3 a protein?

Caspase 3 is a relatively small protein that consists of 2 subunits, a 12- and 17-kDa subunit that contains 3 and 5 thiol functions, respectively.

Which types of arrhythmias are narrow complex tachyarrhythmias?

Atrial tachycardia is usually a narrow complex tachyarrhythmia accounting for 5-15% of supraventricular tachycardias (SVTs). It can occur at any age, but there is an increased likelihood if the atria are diseased (hypertension, pulmonary disease, previous cardiac surgery, etc).

Which ECG lead is most important?

The most useful lead is V4R, which is obtained by placing the V4 electrode in the 5th right intercostal space in the mid-clavicular line.

What are myeloid cancers?

Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes a large number of abnormal blood cells. Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow. It is the most common type of acute leukemia in adults.

Is myeloma the same as myeloid leukemia?

Unlike leukemia, a cancer of the immature blood cells you may have heard about, myeloma cells do not usually circulate in the blood stream but typically stay in the bone marrow. The problems myeloma cells cause and treatments used to treat myeloma are also different from leukemia.

Is survivin an oncogene?

Survivin and STAT3

STAT3, an oncogene, is persistently activated by cytokines or growth factors in multiple cancer types, and it plays important roles in tumor cell proliferation, differentiation and survival 85.

Is caspase-3 a marker of apoptosis?

This caspase is responsible for the majority of proteolysis during apoptosis, and detection of cleaved caspase-3 is therefore considered a reliable marker for cells that are dying, or have died by apoptosis. This protocol outlines the quantification of apoptosis by flow cytometric detection of cleaved caspase-3.

How is caspase 1 activated?

A critical step in caspase-1 activation is the assembly of large macromolecular complex through CARD-CARD and pyrin domain–pyrin domain protein-protein interactions to form a scaffold for the recruitment and activation of procaspase-1.

What signs and symptoms would you expect to see in a patient with tachyarrhythmias?

In general, the following symptoms are common to most kinds of tachyarrhythmia:

• heart palpitations (specifically the sensation that your heart is racing and beating much faster than normal)
• elevated pulse.
• lightheadedness.
• fainting.
• chest pain or tightness.
• shortness of breath.

Is SVT wide or narrow complex?

Supraventricular tachycardia (SVT) is a dysrhythmia originating at or above the atrioventricular (AV) node and is defined by a narrow complex (QRS < 120 milliseconds) at a rate > 100 beats per minute (bpm).

What are the 5 types of myocardial infarction?