What is meant by high-throughput screening?
High throughput screening (HTS) is the use of automated equipment to rapidly test thousands to millions of samples for biological activity at the model organism, cellular, pathway, or molecular level.
What is a high throughput technology?
While sequencing information has traditionally been elucidated using a low throughput technique called Sanger sequencing, high throughput sequencing (HTS) technologies are capable of sequencing multiple DNA molecules in parallel, enabling hundreds of millions of DNA molecules to be sequenced at a time.
What is high throughput imaging?
High-throughput imaging (HTI, see Glossary) refers to the use of automated microscopy and image analysis to visualize and quantitatively capture cellular features at a large scale.
What is high throughput computing example?
High-Throughput Computing
The general profile of HTC applications is that they are made up of a large number of tasks of which the execution can last for a considerable amount of time (i.e., weeks or months). Classical examples of such applications are scientific simulations or statistical analyses.
What is the difference between high throughput screening and virtual screening?
Virtual screening, similar to HTS, relies upon assessing a large, diverse library of compounds. The difference is that the compounds in a virtual screening library are contained in databases rather than being physically assembled by the organisation conducting the screen.
When was high throughput screening invented?
1986
This was the origin of HTS in Pfizer in 1986 as a powerful, rational yet empirical approach to identify molecules that modulated targets of therapeutic interest.
How do you explain throughput?
What Is Throughput? Throughput, in business, is the amount of a product or service that a company can produce and deliver to a client within a specified period of time. The term is often used in the context of a company’s rate of production or the speed at which something is processed.
What is high throughput performance?
In computer science, high-throughput computing (HTC) is the use of many computing resources over long periods of time to accomplish a computational task.
What is the difference between high performance computing and high throughput computing?
High-throughput computing (HTC) refers to computations where individual tasks do not need to interact while running. It differs from High-performance (HPC) where frequent and rapid exchanges of intermediate results is required to perform the computations.
What are types of virtual screening?
Virtual Screening
- Virtual High Throughput Screening. Virtual high throughput screening (vHTS) is a methodology which identifies drug candidates from extensive collections of virtual compound libraries.
- Compound Active Site Prediction.
- Structure-Based Screening.
- Ligand-Based Screening.
- Machine Learning Techniques.
Which method is used for virtual screening?
Molecular docking is the most used structure-based technique, and it applies a scoring function to estimate the fitness of each ligand against the binding site of the macromolecular receptor, helping to choose the ligands with the most high affinity.
What is high throughput data?
Page 1. HIGH-THROUGHPUT DATA ANALYSIS. BY SYSTEMS BIOLOGY. “High-throughput data”, the information generated in a massive, fast manner by ‘omics’ technologies – transcriptomics, metabolomics and proteomics – have opened a new era in biomedical research allowing an exponential increase of biomedical discoveries.
What is throughput with example?
Throughput is the number of units that can be produced by a production process within a certain period of time. For example, if 800 units can be produced during an eight-hour shift, then the production process generates throughput of 100 units per hour.
What is another word for throughput?
In this page you can discover 7 synonyms, antonyms, idiomatic expressions, and related words for throughput, like: bandwidth, through-put, bit rate, latency, , efficiency and scalability.
How is throughput measured?
Throughput is usually measured in bits per second (bit/s or bps), and sometimes in data packets per second (p/s or pps) or data packets per time slot. The system throughput or aggregate throughput is the sum of the data rates that are delivered to all terminals in a network.
What are HPC applications?
HPC Applications are specifically designed to take advantage of the parallel nature of high-performance computational computing systems. Algorithmically designed to take advantage of high-performance architecture, these applications can be run on your compute cluster with only minor customization.
What are the types of HPC?
We can differentiate two types of HPC systems: the homogeneous machines and the hybrid ones. Homogeneous machines only have CPUs while the hybrids have both GPUs and CPUs. Tasks are mostly run on GPUs while CPUs oversee the computation. As of June 2020, about 2/3 of supercomputers are hybrid machines.
What is the difference between high-throughput screening and virtual screening?
What is the meaning of virtual screening?
Virtual screening can be defined as a set of computational methods that analyzes large databases or collections of compounds in order to identify potential hit candidates.
What do you mean by virtual screening?
Where is high throughput screening used?
pharmaceutical industry
High-throughput screening methods are extensively used in the pharmaceutical industry, leveraging robotics and automation to quickly test the biological or biochemical activity of a large number of molecules, usually drugs.
What is throughput used for?
Throughput is a measure of how many units of information a system can process in a given amount of time. It is applied broadly to systems ranging from various aspects of computer and network systems to organizations.
What factors affect throughput?
Factors that Affect Throughput
- Transmission Medium Limitation. Like we said above, bandwidth (or the theoretical capacity) of a particular transmission medium will limit the throughput over that medium.
- Enforced Limitation.
- Network Congestion.
- Latency.
- Packet Loss and Errors.
- Protocol Operation.
What are the three key components of HPC?
There are three key components of high-performance computing solutions: compute, network, and storage. In order to develop a high performance computing architecture, multiple computer servers are networked together to form a cluster.
What is HPC example?
A supercomputer is one of the best-known examples of HPC, in which one large computer is made up of many computers and processors that work together to achieve parallel processing and high performance.