What is the distribution coefficient for the solute?
The distribution coefficient is defined as the concentration of solute in the organic solvent divided by the concentration of solute in the aqueous phase.
What is distribution coefficient in solvent extraction?
The distribution coefficient is the ratio of the concentration of solute in the organic phase over the concentration of solute in the aqueous phase (the V-terms are the volume of the phases).
What does the distribution coefficient tell you?
Thus, the partition-coefficient or the distribution-coefficient is the ratio of the respective equilibrium concentrations of a chemical in a mixture of two immiscible phases and is also a measure of the difference in solubility of the chemical in the two phases.
How do you calculate distribution coefficient?
By the concentration of the solute in the aqueous. Phase. This ratio is approximately the same as dividing the solute solubility. In the organic solvent by its solubility.
What does a higher distribution coefficient mean?
unit of measure called the partition coefficient. The greater the solubility of a substance, the higher its partition coefficient, and the higher the partition coefficient, the higher the permeability of the membrane to that particular substance.
What does distribution coefficient depend on?
The distribution constants are dependent on various parameters including temperature, pressure and sample matrix conditions such as pH, salt and organic component concentration. All these parameters need to be optimised for maximum transfer of analytes to the extraction phase during the method development process.
What is the representation of distribution coefficient Mcq?
5. What is the representation of distribution coefficient? Explanation: The distribution coefficient is denoted by K. 6.
How do you calculate distribution coefficient in extraction?
The ratio of solubilities in the two solvents is called the distribution coefficient, KD = C1/C2, which is an equilibrium constant with a characteristic value for any compound at a given temperature. The total amount extracted by 100 mL as 2 x 50 mL portions of ether is thus 0.92 g.
What is the distribution coefficient k?
Partition/Distribution Coefficient (K)
When equilibrium has established, the ratio of concentration of solute in each layer is constant for each system, and this can be represented by a value K (called the partition coefficient or distribution coefficient). K=Molarity in organic phaseMolarity in aqueous phase.
What is the relationship between solubility and distribution coefficient?
The greater the solubility of a substance, the higher its partition coefficient, and the higher the partition coefficient, the higher the permeability of the membrane to that particular substance.
What is the measure of dispersion in interval scale Mcq?
Standard Deviation, Variance, and Range are measures of dispersion but the Mean, Mode, and Median are the measure of central tendency.
What should be the Range of oil water partition coefficient of any drug Mcq?
11. What should be the range of oil/water partition coefficient of any drug? Explanation: The octanol/pH 7.4 buffer partition coefficient value for a drug should be in the range of 1-2. This is sufficient for passive absorption across lipodial membranes.
How do you calculate distribution ratio in solvent extraction?
Derive an expression for percentage extraction? | Solvent Extracton
Which of the following is true for coefficient of correlation Mcq?
The coefficient of correlation is the square root of the coefficient of determination. d. The zero value of the correlation coefficient cannot estimate the value of the dependent variable. Only d is true.
Which one is measure of dispersion method Mcq?
Mean, Standard Deviation; Variance is the measure used to calculate dispersion.
Which of the solvent is most suitable for determining the partition coefficient which have relevance for drug transport across biological membrane?
The partition coefficient is determined by the shake flask method using two immiscible solvents, the most common hydrophilic solvent is water or phosphate buffer of pH 7.4, and for oil phase is octanol.
What is distribution coefficient k?
What is the smallest distribution ratio for a solute S if you want to extract 99.9% of S from 50.0 mL of aqueous phase using two 25.0 mL portions of the organic solvent?
61.25
Question 2 (7 points).
What is the smallest distribution ratio for a solute, S, if you want to extract 99.9% of S from 50.0 mL of aqueous phase using two 25.0-mL portions of the organic solvent? gives its value as 61.25; this is the smallest possible value for D.
What is the range of correlation coefficient Mcq?
between 0 and 1
Correlation Coefficient MCQ Question 2 Detailed Solution
It is the value ranges between 0 and 1. It cannot assume a minus value.
What do correlation coefficients positive negative and zero mean?
If the correlation coefficient is greater than zero, it is a positive relationship. Conversely, if the value is less than zero, it is a negative relationship. A value of zero indicates that there is no relationship between the two variables.
What is the formula for coefficient of average deviation from median?
The coefficient of mean deviation is calcvilated by dividing mean deviation by the average. If deviations are taken from mean, we divide it by mean, if the deviations are taken from median, then it is divided by mode and if the “deviations are taken from median, then we divide mean deviation by median.
How do you calculate standard deviation Mcq?
Formula Used:
Standard deviation = √[(Σx2)/N] , where Σx2 is the summation of the square of deviation of all observations from Mean.
What solvents are used when determining the partition coefficient for pharmaceutical drugs and why are they used?
Most commonly, one of the solvents is water, while the second is hydrophobic, such as 1-octanol. Hence the partition coefficient measures how hydrophilic (“water-loving”) or hydrophobic (“water-fearing”) a chemical substance is. Partition coefficients are useful in estimating the distribution of drugs within the body.
Which of the following factors influence absorption of drug Mcq?
Explanation: Disintegration time is of importance in the case of solid dosage forms like tablets and capsules. Disintegration time is the time taken by the capsule to disintegrate into smaller particles.
What is the relation between distribution coefficient and distribution ratio?
Partition Coefficients and Distribution Ratios
The partition coefficient is a thermodynamic equilibrium constant and has a fixed value for the solute’s partitioning between the two phases. The distribution ratio’s value, however, changes with solution conditions if the relative amounts of A and B change.