What kind of bacteria is Proteus?
Proteus species are part of the Enterobacteriaceae family of gram-negative bacilli. The first isolates were reported and characterized by Hauser in the late 19th century. The genus is currently composed of Proteus mirabilis, Proteus vulgaris, Proteus penneri, Proteus hauseri, Proteus terrae, and Proteus cibarius.
What is Proteus spp infection?
Proteus mirabilis is a Gram-negative bacterium which is well-known for its ability to robustly swarm across surfaces in a striking bulls’-eye pattern. Clinically, this organism is most frequently a pathogen of the urinary tract, particularly in patients undergoing long-term catheterization.
Where is Proteus spp found?
It should be noticed that Proteus spp. are the most prevalent bacteria, isolated from bladder and kidney stones (70 % of cases). P. mirabilis is the main cause of all Proteus spp.
How do you identify Proteus bacteria?
It is oxidase-negative but catalase- and nitrate-positive. Specific tests include positive urease (which is the fundamental test to differentiate Proteus from Salmonella) and phenylalanine deaminase tests. On the species level, indole is considered reliable, as it is positive for P. vulgaris, but negative for P.
What causes Proteus?
How is Proteus mirabilis transmitted? The bacterium spreads mainly through contact with infected persons or contaminated objects and surfaces. The pathogens can also be ingested via the intestinal tract, for example, when it is present in contaminated food. The germs spread quickly because they are very agile.
What antibiotics treat Proteus?
For hospitalized patients, therapy consists of parenteral (or oral once the oral route is available) ceftriaxone, quinolone, gentamicin (plus ampicillin), or aztreonam until defervescence. Then, an oral quinolone, cephalosporin, or TMP/SMZ for 14 days may be added to complete treatment.
What causes Proteus infection?
What does Proteus spp cause?
The most common clinical manifestations of Proteus infection are urinary tract infections (UTIs). In general, UTIs are more common in individuals aged 20 to 50 years and most common in women of this age group. In otherwise healthy women, Proteus accounts for 1% to 2% of all UTIs (E.
How is Proteus spp transmitted?
MODE OF TRANSMISSION: Proteus spp. are part of the human intestinal flora 1 3- 5 and can cause infection upon leaving this location. They may also be transmitted through contaminated catheters (particularly urinary catheters) 1 4 5 or by accidental parenteral inoculation.
What are the symptoms of Proteus infection?
Proteus can cause gastroenteritis, urinary tract infections, and wound infections. The ingestion of food contaminated by Proteus may contribute to the sporadic and epidemic cases of gastroenteritis, which may cause symptoms such as vomiting, fever, abdominal pain, severe nausea, diarrhea, and dehydration.
How do you prevent Proteus?
Proteus is more common in people who have or have had a urinary catheter. Minimizing the incidence and duration of urinary catheterization is an important part of preventing infection. Community staff who are alert to the possibility of this infection can make a huge difference to their patient’s quality of life.
Is Proteus infection serious?
Proteus is found abundantly in soil and water, and although it is part of the normal human intestinal flora (along with Klebsiella species, and Escherichia coli), it has been known to cause serious infections in humans.
What antibiotic kills Proteus?
The tested antibiotics included: ciprofloxacin, ceftriaxone, nitrofurantoin, and gentamicin. Of them, ciprofloxacin showed the highest activity. Up to 93% reduction in biofilm formation was achieved using a concentration of ciprofloxacin corresponding to 1/2MIC.
How do you treat Proteus bacteria?
Acute, uncomplicated pyelonephritis can be treated on an outpatient basis with fluoroquinolones, although a regimen of 7 to 14 days is recommended. An alternative to this treatment is a one-time dose of ceftriaxone or gentamycin followed by either TMP/SMZ, an oral fluoroquinolone, or cephalosporin for 7 to 14 days.
What causes Proteus UTI?
Proteus mirabilis (PM) is a Gram-negative rod-shaped bacterium and widely exists in the natural environment, and it is most noted for its swarming motility and urease activity. PM is the main pathogen causing complicated urinary tract infections (UTIs), especially catheter-associated urinary tract infections.