What is IgG4-related systemic disease?
IgG4-related disease is a fibro-inflammatory condition that can affect nearly any organ system. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis.
What is the treatment for IgG4?
Treatment for IgG4-RSD traditionally has involved prednisone, a steroid medication. Prednisone has proven very effective in treating this condition but also leads to side effects such as weight gain, osteoporosis, high blood pressure and diabetes.
What are the symptoms of autoimmune pancreatitis?
Autoimmune pancreatitis can cause a variety of complications. Pancreatic exocrine insufficiency. AIP may affect the ability of your pancreas to make enough enzymes. Signs and symptoms may include diarrhea, weight loss, metabolic bone disease, and vitamin or mineral deficiency.
Can an autoimmune disease cause swollen lymph nodes?
Autoimmune diseases can cause lymph node swelling, too. Usually, the lymph node swelling in autoimmune diseases is in multiple areas of the body.
Can pancreatitis affect lymph nodes?
This disease often affects multiple organs including the pancreas, bile ducts in the liver, salivary glands, kidneys and lymph nodes.
Is IgG4 disease serious?
IgG4-RD can cause many different symptoms and may affect one or several organs at the same time or at different times. Although symptoms may sometimes be mild, it can also cause severe organ damage and even death if not treated.
How is IgG4-RD differentiated from lymphadenopathy?
Therefore, IgG4-RD, and especially IgG4-related lymphadenopathy, cannot be differentiated on the basis of histological findings alone. The diagnosis of IgG4-RD needs to be based not only on pathological findings but also on clinical and laboratory findings.
Does immunoglobulin G4 cause lymphadenopathy?
Immunoglobulin G4-related disease (IgG4-RD) frequently involves lymph nodes in a localized or systemic fashion [1–3]. Indeed, approximately 80% of patients with autoimmune pancreatitis (IgG4-related pancreatitis) has lymphadenopathy, most commonly involving the mediastinal and intraabdominal lymph nodes .
What is lymphadenopathy in dogs?
Lymphadenopathy in Dogs. Lymphadenitis is a condition in which the lymphatic glands have become inflamed due to infection. Neutrophils (the most abundant type of white blood cell, and the first to act against infection), activated macrophages (cells which eat bacteria and other infectious agents), and eosinophils…
Where was IgG4-related lymphoproliferative disorder discovered?
Masaki Y, Kurose N, Umehara H. IgG4-related disease: a novel lymphoproliferative disorder discovered and established in Japan in the 21st century. Journal of Clinical and Experimental Hematopathology.